Most Read Articles
Roshini Claire Anthony, 28 Sep 2015

Individuals with chronic ischaemic heart disease (IHD) and a small left ventricle and thick myocardium demonstrated higher levels of cardiac remodelling as opposed to those with a large ventricle and thin myocardium, contrary to the prevailing understanding, according to the DOPPLER-CIP study. 

18 Aug 2016
Chronic kidney disease (CKD), regardless of the stage, appears to have no direct effect on cardiovascular mortality within 180 days and 2 years from digoxin treatment initiation in treatment-naïve patients with non-valvular atrial fibrillation (AF), a Danish cohort study suggests.
Yesterday
The presence of target organ damage (TOD) in hypertension is more likely to result in blood pressure (BP) elevation, independently of the type of measurement (office or ambulatory, central or peripheral), according to a recent study. Central BP, even monitored during 24 hours, is not better correlated with TOD than peripheral BP.
19 Jun 2017
There is no evidence to support the association between neurofibromatosis type 1 and intracranial aneurysms, a new population-based study shows. Moreover, there is no rise in the incidence of aneurysmal subarachnoid haemorrhage in NF1 patients.

Right ventricular end-systolic remodelling index predicts outcomes in pulmonary arterial hypertension

12 Jul 2017
Donors' organs are distributed based on clinical criteria, such as waiting times, and suitability between donors and recipients.

The right ventricular end-systolic remodelling index (RVESRI) is a simple and good prognostic marker of outcomes in patients with pulmonary arterial hypertension, a new study shows.

Univariate analysis revealed that New York Heart Association class (NYHA; hazard ratio [HR], 3.36; 95 percent CI, 2.10 to 5.38; p<0.001), serum levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP; HR, 1.95; 1.57 to 2.42; p<0.001), right ventricular free wall longitudinal strain (RVLS; HR, 0.63; 0.51 to 0.82; p<0.001) and RVESRI (HR, 2.05; 1.66 to 2.53; p<0.001) were all significantly associated with death, transplant or admission.

After multivariate analysis, only NYHA class (HR, 1.96; 1.14 to 3.37; p=0.01), NT-proBNP levels (HR, 1.32; 1.01 to 1.73; p=0.04) and RVESRI (HR, 1.58; 1.22 to 2.04; p=0.001) remained significant predictors of the primary endpoint of death, lung transplant or admission for heart failure.

A comparison of other indices of RV end-systolic size or transverse-to-longitudinal ratio showed that RVESRI (χ2, 62; p<0.0001) was more accurately associated with the outcome than RV end-systolic area (RVESA)/height (χ2, 52; p<0.0001), RVESA/body surface area (χ2, 48; p<0.0001) and other indices.

The final model for the primary endpoint included NYHA class, RVESRI and NT-proBNP levels (χ2, 62.2; p<0.0001). The final model for the secondary endpoint of death or lung transplant included RVESRI and NT-proBNP levels (χ2, 42.40; p<0.0001).

The study included 228 pulmonary arterial hypertension patients (mean age 49±14 years; 78 percent female). RVESRI was calculated by dividing the lateral length by the septal height, both measured from echocardiographs.

Over a mean follow-up of 3.9±2.4 years, 43 deaths, 15 transplants and 30 admissions were reported, yielding a total of 88 events for the primary endpoint and 58 for the secondary endpoint.

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Most Read Articles
Roshini Claire Anthony, 28 Sep 2015

Individuals with chronic ischaemic heart disease (IHD) and a small left ventricle and thick myocardium demonstrated higher levels of cardiac remodelling as opposed to those with a large ventricle and thin myocardium, contrary to the prevailing understanding, according to the DOPPLER-CIP study. 

18 Aug 2016
Chronic kidney disease (CKD), regardless of the stage, appears to have no direct effect on cardiovascular mortality within 180 days and 2 years from digoxin treatment initiation in treatment-naïve patients with non-valvular atrial fibrillation (AF), a Danish cohort study suggests.
Yesterday
The presence of target organ damage (TOD) in hypertension is more likely to result in blood pressure (BP) elevation, independently of the type of measurement (office or ambulatory, central or peripheral), according to a recent study. Central BP, even monitored during 24 hours, is not better correlated with TOD than peripheral BP.
19 Jun 2017
There is no evidence to support the association between neurofibromatosis type 1 and intracranial aneurysms, a new population-based study shows. Moreover, there is no rise in the incidence of aneurysmal subarachnoid haemorrhage in NF1 patients.