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Rheumatoid arthritis ups risk of CVD, CHF

11 Jul 2017
Mesoblast cell treatment shows promise for rheumatoid arthritis

The risks of cardiovascular disease (CVD) and congestive heart failure (CHF) are twice as higher in rheumatoid arthritis (RA) patients than in osteoarthritis (OA) patients, a new cross-sectional study in a Chinese population shows.

Comparing the medical records of 1,022 OA (mean age 58.5±0.4 years; 68.7 percent female) and RA (mean age 57.8 years; 68. Percent female) patients, matched by sex and age, a significantly higher prevalence of CVD (adjusted OR [OR], 2.19; 95 percent CI, 1.49 to 2.95; p<0.05) in the RA cohort was found.

CHF (adjusted OR, 6.95; 1.50 to 32.21; p<0.05) and atherosclerosis (adjusted OR, 4.95; 3.36 to 7.28; p<0.05) were also significantly more common in RA vs OA patients.

There was no significant difference in the prevalence of ischaemic heart disease (adjusted OR, 1.83; 0.94 to 3.56) and stroke (adjusted OR, 1.13; 0.57 to 2.25).

Before matching, the prevalence of CVD (adjusted OR, 1.86; 1.42 to 2.43; p<0.05) was also significantly greater in RA (n=1,824; mean age 52.4±0.5 years; 96.9 percent female) than in OA (n=1,995; mean age 63.0±0.3 years; 74.6 percent female) patients.

Similar trends were reported for CHF (adjusted OR, 2.09; 1.03 to 4.22; p<0.05) and atherosclerosis (adjusted OR, 2.49; 1.97 to 3.13; p<0.05).

The medical record database of Sichuan’s provincial people’s hospital was scoured for inpatients with principal diagnoses of RA or OA. Those principally diagnosed with both RA and OA were excluded.

Stroke and CVD were the primary outcomes while specific CVDs, such as IHD, atherosclerosis and CHF, were the secondary outcomes.

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Most Read Articles
2 days ago
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
3 days ago
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.
Jairia Dela Cruz, 3 days ago
Laparoscopic sleeve gastrectomy (SG) appears to be effective in Asians, with early weight loss correlating with midterm weight maintenance and remission of obesity-related comorbidities 1 year after the surgery, according to a study.