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Elvira Manzano, 4 days ago
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Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
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Tristan Manalac, Yesterday
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Rheumatoid arthritis ups risk of CVD, CHF

11 Jul 2017
Mesoblast cell treatment shows promise for rheumatoid arthritis

The risks of cardiovascular disease (CVD) and congestive heart failure (CHF) are twice as higher in rheumatoid arthritis (RA) patients than in osteoarthritis (OA) patients, a new cross-sectional study in a Chinese population shows.

Comparing the medical records of 1,022 OA (mean age 58.5±0.4 years; 68.7 percent female) and RA (mean age 57.8 years; 68. Percent female) patients, matched by sex and age, a significantly higher prevalence of CVD (adjusted OR [OR], 2.19; 95 percent CI, 1.49 to 2.95; p<0.05) in the RA cohort was found.

CHF (adjusted OR, 6.95; 1.50 to 32.21; p<0.05) and atherosclerosis (adjusted OR, 4.95; 3.36 to 7.28; p<0.05) were also significantly more common in RA vs OA patients.

There was no significant difference in the prevalence of ischaemic heart disease (adjusted OR, 1.83; 0.94 to 3.56) and stroke (adjusted OR, 1.13; 0.57 to 2.25).

Before matching, the prevalence of CVD (adjusted OR, 1.86; 1.42 to 2.43; p<0.05) was also significantly greater in RA (n=1,824; mean age 52.4±0.5 years; 96.9 percent female) than in OA (n=1,995; mean age 63.0±0.3 years; 74.6 percent female) patients.

Similar trends were reported for CHF (adjusted OR, 2.09; 1.03 to 4.22; p<0.05) and atherosclerosis (adjusted OR, 2.49; 1.97 to 3.13; p<0.05).

The medical record database of Sichuan’s provincial people’s hospital was scoured for inpatients with principal diagnoses of RA or OA. Those principally diagnosed with both RA and OA were excluded.

Stroke and CVD were the primary outcomes while specific CVDs, such as IHD, atherosclerosis and CHF, were the secondary outcomes.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.