Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Rheumatoid arthritis tied to higher risk of bone fractures

04 Oct 2017

Both males and females with rheumatoid arthritis (RA) suffer from significantly higher risks of bone fracture than those without RA, according to a new meta-analysis. Specifically, the risks of hip and vertebral fractures are elevated in RA patients.

“Our study concludes that RA is a risk factor for bone fracture in men and women, with a comparable risk of fracture at the hip and vertebral. Patients with RA are to be monitored more closely to control bone loss and prevent fracture,” said researchers.

The meta-analysis included 13 studies, of which nine scored eight in the Newcastle-Ottawa Scale (NOS), two scored seven and the other two scored six. Overall, the studies were considered to have high methodological quality.

In the meta-analysis, patients with RA showed a significantly higher risk of getting a bone fracture compared to those without RA (risk ratio [RR], 2.25; 95 percent CI, 1.76 to 2.87; p=0.000). The analysis showed significant heterogeneity (p<0.0001) and thus warranted subgroup analyses.

Dividing the subjects by sex showed that both males (RR, 1.87; 1.48 to 2.37) and females (RR, 1.99; 1.58 to 2.50) with RA have higher bone fracture risks than their non-RA counterparts.

Pooled data from seven studies showed that RA was significantly associated with the risk of vertebral fractures (RR, 2.93; 2.25 to 3.83). Similarly, the seven studies that focused on hip fractures revealed a significant and positive correlation between RA and risk of hip fractures (RR, 2.41; 1.83 to 3.17).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.