Most Read Articles
Pearl Toh, 7 days ago
Mepolizumab added on to standard of care for patients with severe eosinophilic asthma better improves health-related quality of life (HRQOL), along with improved asthma symptoms and lung function compared with placebo, according to the MUSCA* study.
Pearl Toh, 6 days ago
Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
5 days ago
Blood pressure (BP) ≥140/90 mm Hg appears to increase the risk of maternal complications and adverse foetal outcomes, irrespective of the number of medications used, a study suggests. However, the greatest risk is observed among pregnant women taking multiple agents and whose BP levels are within the aforementioned range.
7 days ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.

Resveratrol helps attenuate pain in age-related osteoarthritis

19 days ago

Treatment with resveratrol appears to effectively reduce chronic pain in age-related osteoarthritis, in addition to enhancing perceptions of well-being in postmenopausal women, according to a study.

The study randomized 80 healthy postmenopausal women to receive resveratrol (75 mg twice daily) or placebo for 14 weeks.

Aspects of well-being, including pain, menopausal symptoms, sleep quality, depressive symptoms, mood states and quality of life, were assessed at baseline and at the end of treatment using the Short form-36 questionnaire. Rating scales were then averaged to provide a composite score representing overall well-being. Cerebrovascular function was evaluated by measuring cerebral vasodilator responsiveness to hypercapnia.

Compared with placebo treatment, resveratrol supplementation produced a significant reduction in pain as well as an improvement in total well-being. Both benefits, along with measures of quality of life, were associated with improvements in cerebrovascular function.

Commonly found in grapes, berries and nuts, the phytoestrogen resveratrol has been shown to have cardiovascular and neurological benefits—helping attenuate learning impairment and hippocampal degeneration. In vitro studies have also demonstrated the ability of resveratrol to mediate OA-protective effects, including antiapoptotic, anti-inflammatory and antioxidant effects. [Nutrients 2016;8:233; Arthritis Rheum 2008;58:2786–2797; Biochem Pharmacol 2008;75:677–687; Int J Mol Sci 2014;15:6925–6940].

The present data provide evidence of the potential of resveratrol to reduce chronic pain in age-related osteoarthritis, as well as boost perceptions of well-being in postmenopausal women. Regardless, more studies are warranted to elucidate the mechanisms underlying these benefits.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Pearl Toh, 7 days ago
Mepolizumab added on to standard of care for patients with severe eosinophilic asthma better improves health-related quality of life (HRQOL), along with improved asthma symptoms and lung function compared with placebo, according to the MUSCA* study.
Pearl Toh, 6 days ago
Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
5 days ago
Blood pressure (BP) ≥140/90 mm Hg appears to increase the risk of maternal complications and adverse foetal outcomes, irrespective of the number of medications used, a study suggests. However, the greatest risk is observed among pregnant women taking multiple agents and whose BP levels are within the aforementioned range.
7 days ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.