Resveratrol helps attenuate pain in age-related osteoarthritis
Treatment with resveratrol appears to effectively reduce chronic pain in age-related osteoarthritis, in addition to enhancing perceptions of well-being in postmenopausal women, according to a study.
The study randomized 80 healthy postmenopausal women to receive resveratrol (75 mg twice daily) or placebo for 14 weeks.
Aspects of well-being, including pain, menopausal symptoms, sleep quality, depressive symptoms, mood states and quality of life, were assessed at baseline and at the end of treatment using the Short form-36 questionnaire. Rating scales were then averaged to provide a composite score representing overall well-being. Cerebrovascular function was evaluated by measuring cerebral vasodilator responsiveness to hypercapnia.
Compared with placebo treatment, resveratrol supplementation produced a significant reduction in pain as well as an improvement in total well-being. Both benefits, along with measures of quality of life, were associated with improvements in cerebrovascular function.
Commonly found in grapes, berries and nuts, the phytoestrogen resveratrol has been shown to have cardiovascular and neurological benefits—helping attenuate learning impairment and hippocampal degeneration. In vitro studies have also demonstrated the ability of resveratrol to mediate OA-protective effects, including antiapoptotic, anti-inflammatory and antioxidant effects. [Nutrients 2016;8:233; Arthritis Rheum 2008;58:2786–2797; Biochem Pharmacol 2008;75:677–687; Int J Mol Sci 2014;15:6925–6940].
The present data provide evidence of the potential of resveratrol to reduce chronic pain in age-related osteoarthritis, as well as boost perceptions of well-being in postmenopausal women. Regardless, more studies are warranted to elucidate the mechanisms underlying these benefits.