Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

2 days ago
A recent study suggests that discontinuation of dexamethasone premedication after two uneventful infusions or reduction in the dose of dexamethasone paclitaxel premedication are both safe alternatives to high-dose steroid premedications recommended in product labelling.
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Relamorelin effective, safe for diabetic patients with gastroparesis

28 Aug 2017

Relamorelin appears to be effective in reducing core symptoms of gastroparesis, as well as improving overall composite symptom severity score and accelerated gastric emptying (GE), in diabetic patients with moderate to severe gastroparesis, according to the results of a phase IIB trial.

Researchers randomly assigned 393 patients with gastroparesis to groups given placebo (n=104) or relamorelin at a dose of 10 μg (n=98), 30 μg (n=109) or 100 μg (n=82) twice daily for 12 weeks, following a 2-week, single-blind, placebo run-in period. The median age of the cohort was 58.2 years, majority were female (62.3 percent), and 9.9 percent had type 1 diabetes. Median body mass index and HbA1c level were 31.4 kg/m2 and 7.6 percent, respectively.

All patients presented with 13C-spirulina GE breath test T1/2 values of ≥79 min (with 89.8 percent delayed relative to 90th percentile of normal, 85.75 minutes), recent vomiting and gastroparesis cardinal symptom index-daily diary scores of ≥2.6.

Patients kept daily e-diaries to record vomiting frequency and gastroparesis symptom (nausea, abdominal pain, postprandial fullness and bloating) scores on a scale of 0 to 10. Endpoints investigated included change from baseline in vomiting frequency, composite gastroparesis symptom severity score, GE and safety. Analysis was performed using longitudinal, mixed-effects model with repeated measures, including baseline and baseline-by-week interaction values as covariates.

Results showed that patients on relamorelin had a 75-percent reduction from baseline in vomiting frequency, but this difference was not significant when compared with the placebo group. A significant reduction was seen in all four symptoms of gastroparesis (composite or individual symptoms) over the 12-week study period in all three relamorelin dose groups vs placebo (p<0.05 for all).

Compared with placebo, relamorelin also significantly accelerated GE from baseline (p<0.05 for the 10 and 30 μg groups; p=0.051 for the 100 μg group). Dose-related worsening of glycaemic control was observed in 14.5 percent of patients who received relamorelin, with some requiring insulin or other diabetes drug dosage adjustments.

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Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

2 days ago
A recent study suggests that discontinuation of dexamethasone premedication after two uneventful infusions or reduction in the dose of dexamethasone paclitaxel premedication are both safe alternatives to high-dose steroid premedications recommended in product labelling.
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.