Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Reasons why clinicians do not recommend adjuvant chemotherapy

19 Mar 2017

A recent study shows that discussion at a multidisciplinary meeting enables the identification of cancer patients unsuitable for adjuvant therapy.

Researchers argue that the reasons for refusing chemotherapy should be fully examined to make sure that treatment preferences of patients are balanced against the proven benefits of chemotherapy.

To determine reasons why clinicians do not recommend adjuvant chemotherapy and why patients decline recommended chemotherapy, a retrospective, single institution Australian study was conducted on all surgically managed stage III colon cancer patients diagnosed at the regional cancer centre at Toowoomba Hospital between July 2010 and December 2014.

Of the 109 patients suitable for evaluation, 72 (66.1 percent) received adjuvant chemotherapy. Clinicians did not recommend chemotherapy in 25 (23.4 percent) patients, with the majority (68 percent) having more than one cited reason.

The most common reasons for not recommending chemotherapy were multiple comorbidities and advanced age (p<0.01). Age alone was not a reason for nonrecommendation.

There were 12 (11 percent) patients who refused chemotherapy despite recommendation. Majority of patient charts (63.6 percent) did not elaborate the reasons for refusal. Travel distance did not count as a factor in accepting or declining chemotherapy.

“Attendance at a regional cancer centre provides the opportunity for high standard care in the management of stage III colon cancer,” researchers suggested.

These findings were similar to a 2012 study on surgically treated stage III colon cancer patients, which found that the most frequent reason for not recommending adjuvant chemotherapy was the presence of one or more comorbidities, or combination of comorbidity and age or frailty. [BMC Res Notes 2012;5:269]

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.