Most Read Articles
08 Oct 2017
Treatment with vismodegib does not appear to increase the risk of subsequent squamous cell carcinoma (SCC) in comparison with standard surgical treatment of basal cell carcinoma (BCC), a recent study suggests.
Stephen Padilla, 10 Oct 2017
Secukinumab has shown efficacy and safety for patients with extensive moderate-to-severe scalp psoriasis, according to a recent study.
09 Oct 2017
Use of voriconazole appears to increase the risk specifically for squamous cell carcinoma (SCC) in the allogeneic haematopoietic cell transplantation (HCT) population, according to a recent study.
27 Sep 2017
Poor sleep quality is not uncommon among patients with psoriatic disease, suggests a recent study. Poor sleep is associated with fatigue, anxiety and lower EQ-5D. It is also associated with actively inflamed joints in patients with psoriatic arthritis (PsA).

Radiologic imaging on par with histopathology in diagnosis of calciphylaxis

08 Aug 2017

More rapid diagnosis of calciphylaxis is possible with radiologic imaging when skin biopsy specimen is pending or not available, according to a recent study.

Currently, the gold standard for diagnosis of calciphylaxis is a skin biopsy specimen showing calcification of small-calibre arteries or arterioles, researchers said.

To compare diameters of calcified vessels seen in skin biopsy specimens and radiology images of patients with calciphylaxis, researchers conducted a retrospective study involving patients with known calciphylaxis from 2009 to 2016 at a community hospital who had both skin biopsy specimens and radiology images takes as part of their routine care.

In addition, vascular calcification was compared in skin biopsy specimens and radiology images. There were seven patients included in the study.

Of the patients, three had small-vessel calcification as fine as 0.1 to 0.3 mm on plain films, three had 0.1 to 0.2 mm by mammography, and one had 0.1 to 0.2 mm by computed tomography imaging, nearly as fine a resolution as on histopathology.

These results support a previous study, which found that radiology, used together with histopathological, clinical and laboratory data, can help in the diagnosis of calciphylaxis. [Int J Dermatol 2016;55:e275-9]

The current study, however, is limited by its single-centre design and small sample size, according to researchers.

A syndrome of vascular calcification, calciphylaxis frequently occurs in patients with end-stage renal disease on haemodialysis. It has a high mortality rate, which makes early diagnosis and treatment necessary. [Int J Dermatol 2016;55:e275-9]

Editor's Recommendations
Most Read Articles
08 Oct 2017
Treatment with vismodegib does not appear to increase the risk of subsequent squamous cell carcinoma (SCC) in comparison with standard surgical treatment of basal cell carcinoma (BCC), a recent study suggests.
Stephen Padilla, 10 Oct 2017
Secukinumab has shown efficacy and safety for patients with extensive moderate-to-severe scalp psoriasis, according to a recent study.
09 Oct 2017
Use of voriconazole appears to increase the risk specifically for squamous cell carcinoma (SCC) in the allogeneic haematopoietic cell transplantation (HCT) population, according to a recent study.
27 Sep 2017
Poor sleep quality is not uncommon among patients with psoriatic disease, suggests a recent study. Poor sleep is associated with fatigue, anxiety and lower EQ-5D. It is also associated with actively inflamed joints in patients with psoriatic arthritis (PsA).