Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

PSA declines predict better overall survival in mCRPC

27 Jul 2017

A decline in prostate-specific antigen (PSA) levels is a significant predictor of better overall survival (OS) in highly pretreated patients with metastatic castration-resistant prostate cancer (mCRPC), a new retrospective study reveals.

A retrospective analysis of 129 mCRPC patients on enzalutamide (mean age at diagnosis 66.3±6.3 years) showed that the PSA response rate (>50 percent decline in PSA levels) at 4 weeks was 48.7 percent (n=58).

Additionally, PSA response rates at 8, 12 and 16 weeks were 50.4 (n=58), 49.1 (n=54) and 51.7 (n=47) percent, respectively.

In univariate analysis, a positive PSA response was significantly associated with improved overall survival at 8 (hazard ratio [HR], 0.62; 95 percent CI, 0.41 to 0.94; p=0.023) and 12 (HR, 0.40; 0.26 to 0.62; p<0.001) weeks.

On the other hand, multivariable analysis showed that improved overall survival as significantly related to a positive PSA response only at week 12 (HR, 0.30; 0.16 to 0.57; p<0.001). Survival at week 8 (HR, 0.62; 0.35 to 1.12; p=0.11) was not significantly associated with PSA response. The median overall survival of the cohort was 7.8 months.

Other prognostic factors of overall survival included PSA (HR, 1.49; 1.23 to 1.79; p<0.001), alkaline phosphatase (HR, 1.93; 1.35 to 2.76; p=0.002) and haemoglobin (HR, 0.69; 0.58 to 0.82; p<0.001) levels upon enzalutamide initiation.

Prior treatment with docetaxel (HR, 5.73; 2.73 to 12.02; p<0.001), cabazitaxel (HR, 2.35; 1.57 to 3.52; p<0.001) and abiraterone (HR, 6.54; 3.63 to 11.78; p<0.001) were all also significantly correlated with overall survival.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.