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Prevalence of metabolic syndrome higher in patients with psoriasis

24 Sep 2017

Patients with psoriasis are at an increased risk for metabolic syndrome (MS), which is why clinicians should consider screening these individuals for metabolic risk factors, according to a recent study.

A systematic review and meta-analysis of observational studies on psoriasis and MS in adults was conducted to determine the association between the two. Researchers accessed Medline, Scopus, SciELO, Google Scholar, Science Direct and Lilacs from inception to January 2016.

A random effects model meta-analysis was performed for those studies that report adjusted odds ratios (ORs) with 95 percent CIs. The subgroup analysis was related to geographic location, diagnosis criteria and risk of bias.

A total of 14 papers including 25,042 patients with psoriasis met the inclusion criteria. Overall, 31.4 percent of participants had MS (OR, 1.42; 1.28 to 1.65). Middle Eastern studies (in Israel, Turkey and Lebanon) reported a higher risk for MS (OR, 1.76; 0.86 to 2.67) compared with European studies (in Germany, Italy, UK, Norway and Denmark; OR, 1.40; 1.25 to 1.55).

These findings supported the study by Armstrong and colleagues in 2013. According to their systematic review and meta-analysis of 12 observational studies, patients with psoriasis have higher prevalence of MS than the general population. Furthermore, those with more severe psoriasis are more likely to have MS than those with milder psoriasis. [J Am Acad Dermatol 2013;68:654-62]

The current study is limited by the small number of adjusted studies and the inconsistency between publications, according to researchers.

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Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
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