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Prevalence, parameters of nondiabetic renal disease in patients with heavy proteinuria

26 Sep 2017

Diabetic patients with nephrotic-range proteinuria have altered clinical parameters and prevalence and predictors of nondiabetic renal disease (NDRD), a recent study has shown.

In the study sample of 220 type 2 diabetes patients who underwent renal biopsy, 129 had nephrotic-range proteinuria while the remaining 91 had mild-to-moderate proteinuria. Those with heavy proteinuria had significantly lower serum albumin and higher total cholesterol (p<0.001 for both).

Isolated diabetic nephropathy (DN) and NDRD were diagnosed in 114 and 86 patients, respectively, while 20 were diagnosed to have both NDRD and DN.

Isolated DN was more common in patients with nephrotic-range proteinuria, yielding a prevalence rate of 62.8 percent (n=81). On the other hand, NDRD was more common in patients with mild-to-moderate proteinuria, with a prevalence rate of 60.4 percent (n=55).

Membranous and IgA nephropathy were the most common types of NDRD in patients with heavy and mild-to-moderate proteinuria, respectively.

Multivariate logistic regression adjusted for age, hypertension, sex and estimated glomerular filtration rate (eGFR) was used to determine the clinical predictors of NDRD. Notably, shorter diabetes mellitus (DM) duration was not a significant predictor of NDRD in those with heavy proteinuria (odds ratio [OR], 0.961; 95 percent CI, 0.910 to 1.015; p=0.153).

In contrast, longer DM duration correlated significantly with NDRD in patients with mild-to-moderate proteinuria (OR, 0.898; 0.840 to 0.960; p=0.002).

On the other hand, older age was significantly correlated with NDRD in those with heavy proteinuria (OR, 1.048; 1.013 to 1.084; p=0.006) but not in those with mild-to-moderate proteinuria (OR, 1.02; 0.972 to 0.069; p=0.423).

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
19 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 21 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.