Most Read Articles
01 Mar 2016
The present understanding on the pathogenesis, diagnosis, and management of rheumatic heart disease were discussed in a review.
05 Jun 2015
Acute rheumatic fever and rheumatic heart disease continue to cause serious problems and hospitalisations according to a study in Zimbabwe.
03 Jun 2017
Both high and low values of the atherogenic index of plasma are independently associated with all-cause mortality, a new study reveals.
01 Oct 2015
The earliest evidence of rheumatic heart disease (RHD) in children increases the risk of acute rheumatic heart disease, valvular lesion progression and definite RHD development as stated in a prospective cohort study.

Presence of rheumatoid factor tied to 10-year cardiovascular disease in RA patients

07 Sep 2017

The presence of rheumatoid factor (RF) rather than anticyclic citrullinated peptide antibodies (anti-CCP) may predict 10-year cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA), a recent study has found.

Researchers sought to determine whether anti-CCP and RF were risk factors for 10-year CVD in RA patients by analysing data from the Nijmegen early RA inception cohort, in which those with newly diagnosed RA (n=929), consecutively included since 1985, were followed up regularly. Anti-CCP and RF were determined at baseline during diagnosis.

The first CVD event (ischaemic heart disease, nonhaemorrhagic cerebrovascular accident [CVA] or peripheral artery disease [PAD]) after baseline as retrieved from physician diagnosis was the primary outcome. Researchers checked fatality against death certificates. They performed Cox regression plus correction for baseline confounders to estimate the effect of anti-CCP, RF and their interaction on 10-year CVD-free survival.

Of the included patients, 628 were anti-CCP‒positive and 697 were RF-positive. There were a total of 162 CV events (101 ischaemic heart disease, 45 CVA and 16 PAD), of which 15 were fatal, during a median follow-up of 7.5 years.

The adjusted hazard ratio (aHR) was 1.17 (95 percent CI, 0.82 to 1.67) for anti-CCP and 1.52 (1.00 to 2.30) for RF. There was an even greater association between RF positivity and CVD among anti-CCP‒negative patients (aHR, 2.09; 1.18 to 3.71). No significant interaction was seen between anti-CCP and RF (p=0.098).

In an earlier study involving postmenopausal women, CVD risk strongly correlated with CVD risk factors, joint pain severity and inflammation, but not with anti-CCP positivity or RF positivity. [Arthritis Rheumatol 2015;67:2311-22]

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Most Read Articles
01 Mar 2016
The present understanding on the pathogenesis, diagnosis, and management of rheumatic heart disease were discussed in a review.
05 Jun 2015
Acute rheumatic fever and rheumatic heart disease continue to cause serious problems and hospitalisations according to a study in Zimbabwe.
03 Jun 2017
Both high and low values of the atherogenic index of plasma are independently associated with all-cause mortality, a new study reveals.
01 Oct 2015
The earliest evidence of rheumatic heart disease (RHD) in children increases the risk of acute rheumatic heart disease, valvular lesion progression and definite RHD development as stated in a prospective cohort study.