Most Read Articles
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.
Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.

Presence of rheumatoid factor tied to 10-year cardiovascular disease in RA patients

07 Sep 2017

The presence of rheumatoid factor (RF) rather than anticyclic citrullinated peptide antibodies (anti-CCP) may predict 10-year cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA), a recent study has found.

Researchers sought to determine whether anti-CCP and RF were risk factors for 10-year CVD in RA patients by analysing data from the Nijmegen early RA inception cohort, in which those with newly diagnosed RA (n=929), consecutively included since 1985, were followed up regularly. Anti-CCP and RF were determined at baseline during diagnosis.

The first CVD event (ischaemic heart disease, nonhaemorrhagic cerebrovascular accident [CVA] or peripheral artery disease [PAD]) after baseline as retrieved from physician diagnosis was the primary outcome. Researchers checked fatality against death certificates. They performed Cox regression plus correction for baseline confounders to estimate the effect of anti-CCP, RF and their interaction on 10-year CVD-free survival.

Of the included patients, 628 were anti-CCP‒positive and 697 were RF-positive. There were a total of 162 CV events (101 ischaemic heart disease, 45 CVA and 16 PAD), of which 15 were fatal, during a median follow-up of 7.5 years.

The adjusted hazard ratio (aHR) was 1.17 (95 percent CI, 0.82 to 1.67) for anti-CCP and 1.52 (1.00 to 2.30) for RF. There was an even greater association between RF positivity and CVD among anti-CCP‒negative patients (aHR, 2.09; 1.18 to 3.71). No significant interaction was seen between anti-CCP and RF (p=0.098).

In an earlier study involving postmenopausal women, CVD risk strongly correlated with CVD risk factors, joint pain severity and inflammation, but not with anti-CCP positivity or RF positivity. [Arthritis Rheumatol 2015;67:2311-22]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.
Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.