Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
14 Oct 2017
In pregnant women, adherence to recommended dietary intake of fat and fibre is associated with a more beneficial and richer gut microbiota which, in turn, decreases levels of the inflammation marker glycoprotein acetylation (GlycA), a study has shown.

Preoperative gabapentinoids reduce postoperative pain in spine surgery

30 Sep 2017

Gabapentinoids, when delivered before spine surgery, seem to reduce postoperative pain, morphine-related complications and total morphine consumption, according to a new meta-analysis.

Pooled data from 16 studies showed that preoperative administration of gabapentinoids significantly reduced pain, as measured by the visual analogue scale (VAS), at 6 hours (weighted mean difference [WMD], -10.57; 95 percent CI, -14.52 to -6.63; p=0.02) after surgery.

VAS was also significantly reduced at 12 (WMD, -9.29; -11.74 to -6.85; p=0.000) and 24 (WMD, -7.19; -10.45 to -3.93; p=0.000) hours after surgery following preoperative gabapentinoid administration.

Morphine consumption at 24 hours postoperation was also significantly decreased after gabapentinioid administration (WMD, -18.55; -23.52 to -13.57; p=0.000). Moreover, pregabalin, a type of gabapentinoid, also significantly reduced cumulative consumption of morphine at 48 hours after surgery (WMD, -6.52; -7.78 to -5.25; p=0.000).

In terms of complication, preoperative gabapentinoids had no significant effect on the occurrence of sedation (risk ratio [RR], 1.29; 0.73 to 2.28; p=0.541), dizziness (RR, 1.44; 1.05 to 1.99; p=0.086) and headache (RR, 1.10; 0.70 to 1.73; p=0.431).

There were also no significant changes in the occurrence of somnolence (RR, 1.45; 0.90 to 2.34; p=0.142), visual disturbances (RR, 1.76; 0.90 to 2.34; p=0.142) and urine retention (RR, 0.61; 0.38 to 0.97; p=0.142).

In contrast, gabapentinoids significantly reduced the occurrence of nausea (RR, 0.69; 0.54 to 0.88; p=0.004), vomiting (RR, 0.51; 0.34 to 0.76; p=0.004) and pruritus (RR, 0.34; 0.22 to 0.55; p=0.001).

Editor's Recommendations
Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
14 Oct 2017
In pregnant women, adherence to recommended dietary intake of fat and fibre is associated with a more beneficial and richer gut microbiota which, in turn, decreases levels of the inflammation marker glycoprotein acetylation (GlycA), a study has shown.