Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Prenatal exposure to glucocorticoids not a risk factor for ADHD

11 Oct 2017

Exposure to glucocorticoids (GCs) during the prenatal period does not appear to have any effect on the risk of developing attention-deficit/hyperactivity disorder (ADHD), a study has found.

The study used data from national registries in Denmark and included a cohort of 875,996 singletons born alive between 1996 and 2009. Of these, 42,099 (4.8 percent) were exposed to GCs prenatally, 177,165 (20.2 percent) were born to mothers with previous exposure to GCs, and 656,732 (75 percent) were born to mothers who were never-GC users.

Cumulative incidences of ADHD at 10 years of age were 2.65 percent among prenatally exposed children and 2.03 percent among unexposed children of never users.

At the general population level, compared with no exposure, prenatal exposure to GCs was associated with an increased risk of developing ADHD. The adjusted hazard ratio (aHR) was 1.43 (95 percent CI, 1.24 to 1.65) for systemic exposure and 1.23 (1.15 to 1.31) for local/inhaled exposure.

However, results from subanalyses of former GC users (aHR, 1.25; 1.20 to 1.29) and sibling design (aHR, 1.03; 0.87 to 1.20) indicated that the increased risk of ADHD with prenatal GC use was due to the presence of unmeasured confounding in the comparison with the general population cohort.

Despite the fact that both exogenous and endogenous GCs can cross the placental barrier and potentially affect foetal development, findings of the present study suggest that prenatal exposure to GCs is not a risk factor for developing ADHD, researchers said.

“The cause of ADHD is multifaceted and may involve risk factors common to ADHD and indications for GC treatment, as well as environmental and genetic factors,” they added.

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Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.