Prediabetes and diabetes increases hepatocellular carcinoma risk in Taiwanese men
Results showed that 114 individuals had developed HCC after 394,079 person-years follow-up. The adjusted hazard ratio was 1.59 for prediabetes, and 3.21 for diabetes, with males contributing to a majority of these associations. Prediabetes was also a significant predictor in those with lower total cholesterol, lower low-density-lipoprotein-cholesterol and never smokers. HCC risk was observed to increase rapidly at fasting glucose level of 85 mg/dL in males, showing a non-linear trend. Providing interventions as soon as the detection of prediabetes in males may therefore lessen the risk for HCC.