Most Read Articles
Dr. Joslyn Ngu, 15 Dec 2015
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are superior to chemotherapy as first-line therapy for advanced non-small cell lung cancer (NSCLC) with positive EGFR gene mutations in terms of progression-free survival rates, says an expert.
Roshini Claire Anthony, 28 Dec 2015
Adjuvant capecitabine therapy significantly improved disease-free survival (DFS) in HER2-negative primary breast cancer patients with residual invasive disease after neoadjuvant chemotherapy (NAC), according to results of the CREATE-X* trial presented at the recent San Antonio Breast Cancer Symposium 2015 in San Antonio, Texas, US.
Jenny Ng, 26 Aug 2015

A study reveals yet another benefit with regular aspirin use, this time showing a reduction in the long-term risk of hereditary colorectal cancer (CRC) in obese patients with Lynch syndrome (LS), a condition caused by mutations in the mismatch repair (MMR) genes. 

Naomi Rodrig, 23 Oct 2015
Pneumonitis is a rare but potentially fatal side effect of immune checkpoint antibodies that target the programmed death-1 receptor and programmed death-ligand 1 [PD-1/PD-L1] pathway, and clinical caution is recommended in order to deliver appropriate urgent treatment.

Prediabetes and diabetes increases hepatocellular carcinoma risk in Taiwanese men

Fiel Soliven
18 Mar 2015
The connection between prediabetes, diabetes, and risk of hepatocellular carcinoma (HCC) in HBsAg and anti-HCV seronegative patients, as well as the association between fasting glucose and HCC, was examined in this study. An initial 79,940 eligible residents participated in the present Keelung Community-Based Integrated Screening program, and were followed-up between 1999 and 2007.

Results showed that 114 individuals had developed HCC after 394,079 person-years follow-up. The adjusted hazard ratio was 1.59 for prediabetes, and 3.21 for diabetes, with males contributing to a majority of these associations. Prediabetes was also a significant predictor in those with lower total cholesterol, lower low-density-lipoprotein-cholesterol and never smokers. HCC risk was observed to increase rapidly at fasting glucose level of 85 mg/dL in males, showing a non-linear trend. Providing interventions as soon as the detection of prediabetes in males may therefore lessen the risk for HCC.
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Most Read Articles
Dr. Joslyn Ngu, 15 Dec 2015
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are superior to chemotherapy as first-line therapy for advanced non-small cell lung cancer (NSCLC) with positive EGFR gene mutations in terms of progression-free survival rates, says an expert.
Roshini Claire Anthony, 28 Dec 2015
Adjuvant capecitabine therapy significantly improved disease-free survival (DFS) in HER2-negative primary breast cancer patients with residual invasive disease after neoadjuvant chemotherapy (NAC), according to results of the CREATE-X* trial presented at the recent San Antonio Breast Cancer Symposium 2015 in San Antonio, Texas, US.
Jenny Ng, 26 Aug 2015

A study reveals yet another benefit with regular aspirin use, this time showing a reduction in the long-term risk of hereditary colorectal cancer (CRC) in obese patients with Lynch syndrome (LS), a condition caused by mutations in the mismatch repair (MMR) genes. 

Naomi Rodrig, 23 Oct 2015
Pneumonitis is a rare but potentially fatal side effect of immune checkpoint antibodies that target the programmed death-1 receptor and programmed death-ligand 1 [PD-1/PD-L1] pathway, and clinical caution is recommended in order to deliver appropriate urgent treatment.