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Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
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Pre-, postchemoradiation NLR predict prognosis in rectal cancer after curative TME

16 Mar 2017

Both pre- and postchemoradiation (CRT) neutrophil-lymphocyte ratio (NLR) have a prognostic value in patients with locally advanced rectal cancer who have received preoperative CRT and curative total mesorectal excision (TME), a new study shows.

The study included 110 patients with rectal cancer or rectal adenocarcinoma who received curative TME after preoperative CRT. Those with fevers, upper respiratory infections, urinary tract infections, rheumatoid diseases, metabolic syndrome or coronary artery disease were excluded.

Three-dimensional radiotherapy was performed simultaneously with chemotherapy with either intravenous 5-fluorouracil or oral capecitabine. NLR before preoperative CRT, during the weekly CRTs and 4 weeks after CRT was calculated.

Participants were grouped into three, according to pre- and post-CRT NLR values: ≤1.75 and ≤5.14, respectively (group A); >1.75 and ≤5.14, or ≤1.75 and >5.14, respectively (group B); and >1.75 and >5.14, respectively (group C). The respective median pre-CRT NLR in these groups were 1.22, 2.24 and 2.86 and median post-CRT NLR were 2.59, 3.13 and 5.86.

The overall 3-year disease-free survival rate was 73.1 percent; for groups A, B and C, these rates were 92.7, 73.0 and 47.3 percent, respectively (p=0.018). The 3-year locoregional recurrence-free survival (LRFS) for group A (96.2 percent) was significantly better compared to groups B (80.7 percent) and C (66.5 percent; p=0.017).

The 3-year distant metastasis-free survival for group C (51.7 percent) was significantly lower compared to groups A (92.7 percent) and B (76.4 percent; p=0.04). For the three groups, overall survival rates were 96.0, 85.5 and 59.8 percent, respectively (p=0.034).

Univariate analysis showed that pre-CRT NLR (p=0.040), post-CRT NLR (p=0.029), NLR group (p=0.027), perineural invasion (p=0.046), pathologic N stage (p=0.038) and pre-CRT carcinoembryonic antigen (CEA; p=0.021) were significantly associated with disease-free survival.

Multivariable analysis, on the other hand, showed that NLR group (p=0.028) and pre-CRT CEA (p=0.035) were the significant prognostic factors for disease-free survival.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.