Most Read Articles
13 Oct 2017
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
12 Oct 2017
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
6 days ago
Excessive intake of the mineral manganese can be toxic to the heart, according to a new study.

Postoperative anti-HBV improves survival, reduces HCC recurrence after resection

15 Aug 2017

Postoperative anti-hepatitis B virus (HBV) therapy is beneficial for patients with intermediate stage hepatocellular carcinoma (HCC) with high HBV-DNA loads, a new observational study has shown.

Investigators classified 202 HCC patients with high preoperative HBV-DNA levels into those who received postoperative anti-HBV therapy (n=118) and those who did not (n=84). Those who received anti-HBV therapy had significantly higher overall survival (p=0.019) and tumour-free survival (p=0.002) rates compared with those who did not.

The 1-, 3- and 5-year overall survival rates were 91.3, 80.9 and 66.1 percent for those who received anti-HBV therapy and 91.7, 60.7 and 52.4 percent for those who did not, respectively.

The 1-, 3- and 5-year tumour-free survival rates for the anti-HBV therapy group were 87.0, 67.0 and 62.6 percent, respectively. For those who did not receive anti-HBV therapy, the corresponding rates were 82.1, 50.0 and 42.9 percent.

Multivariate analysis showed that no postoperative anti-HBV treatment was significantly correlated with a higher risk of recurrence of HCC after resection (hazard ratio [HR], 0.882; 95 percent CI, 0.712 to 0.938; p=0.042).

Over the follow-up period, 90 cases of HCC recurrence were reported, of which 68 were liver recurrences while 22 were metastases to other organs. The most common site of recurrence was the remnant liver (95.6 percent), while the lungs, abdominal lymph nodes and bone were the common sites of metastasis.

There were 79 death events in the 5-year follow-up. The most common cause was HCC recurrence (n=50) followed by decompensated liver cirrhosis (n=16), a combination of these reasons (n=12) and cardiac failure (n=1).

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Most Read Articles
13 Oct 2017
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
12 Oct 2017
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
6 days ago
Excessive intake of the mineral manganese can be toxic to the heart, according to a new study.