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Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

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Postdischarge worsening renal function strongly predicts adverse CV events

11 Sep 2017
Kidney failures and organ donors: Singapore

Postdischarge worsening renal function is common in patients with type 2 diabetes and acute coronary syndromes with normal or mildly depressed renal function, and a strong risk factor for adverse cardiovascular events, according to a recent study.

A total of 204 patients (7.34 percent) had worsening renal function. Over a median follow-up of 2 years, the estimated rates of death and hospital admission for heart failure per 100 person-years were 3.45 (95 percent CI, 2.46 to 6.36) for those with worsening renal function compared with 1.43 (1.14 to 1.79) for patients with stable renal function.

Adjusted analysis revealed that worsening renal function correlated with the composite endpoints of all-cause death and hospitalization for heart failure (hazard ratio, 2.65; 1.57 to 4.49; p<0.001).

In this study, researchers considered the placebo cohort of the AleCardio trial comparing aleglitazar with standard medical therapy among patients with type 2 diabetes mellitus and a recent acute coronary syndrome.

In total, 2,776 patients were included in the analysis. Excluded were those who had died or had been admitted to hospital for heart failure before the 6-month follow-up, as well as patients without complete renal function data.

Worsening renal function was defined as a >20-percent reduction in estimated glomerular filtration rate from discharge to 6 months or progression to macroalbuminuria. Cox regression analysis was used to determine the prognostic impact of 6-month renal deterioration on the composite of all-cause death and hospital admission for heart failure.

“Worsening renal function during hospitalization for an acute coronary syndrome is strongly predictive of in-hospital and long-term outcome,” researchers noted.

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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.