Most Read Articles
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Roshini Claire Anthony, 5 days ago

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Positive outcomes seen in prostatectomy-treated younger men with prostate cancer

14 Jul 2017

Additional evidence suggests that younger men with prostate cancer who are treated with radical prostatectomy mostly have favourable disease characteristics and outcomes.

Researchers evaluated the histopathological features and associated clinical behaviour of prostate cancer in a cohort of younger men (n=171; median age 43 years; range, 38 to 49 years) treated with radical prostatectomy at an academic institution between 2001 and 2015. A comprehensive pathology review was performed.

The authors collected clinical and follow-up data from a prospectively maintained institutional database.

Forty-two percent of the tumours were Gleason score 3+3 and 45 percent were 3+4. On the other hand, 10.5, 0.5 and 1.0 percent of tumours were Gleason score 4+3, 4+4 and 4+5, respectively.

There were 11 cases (6 percent) of mucinous carcinoma (>25 percent extracellular mucin), an uncommon histological variant which comprises 0.2 percent of prostate cancers. Furthermore, 21 cases (12 percent) of acinar adenocarcinoma had a <25 percent mucinous component.

A total of 156 men (91 percent) had available follow-up data. Twelve patients (19 percent) developed biochemical recurrence, but there was no documented postoperative metastasis or death from disease in the cohort.

All cases of mucinous carcinoma were likely to have favourable clinicopathological characteristics.

“While the histopathological features in our series were generally comparable to those of older onset carcinoma, our cohort was enriched for tumours with a mucinous phenotype,” researchers said. “Correlation with molecular-genetic analysis in this subset of tumors may be valuable.”

Prostate cancer is mostly a disease of older men, but younger men with the disease remain a significant clinical subgroup that has not been sufficiently explored, researchers noted.

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Most Read Articles
5 days ago
There appears to be an increased relative risk of small bowel adenocarcinomas in Crohn’s disease (CD) and of small bowel neuroendocrine tumours in both CD and ulcerative colitis, a study suggests.
Roshini Claire Anthony, 5 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

6 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
Yesterday
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.