Most Read Articles
Roshini Claire Anthony, 2 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

6 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
4 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
15 Sep 2017
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.

Plasma tau not elevated in subjective cognitive decline

04 Sep 2017
Tau proteins

Concentrations of the tau proteins in the plasma are not elevated in patients in the premild cognitive impairment (MCI) stage of subjective cognitive decline (SCD), a new study from Germany shows.

Single-molecular array showed that there was no significant difference in the plasma concentrations of the tau protein between SCD patients (3.4 pg/mL) and healthy controls (3.6 pg/mL; p=0.627).

Similarly, cerebrospinal fluid (CSF) concentrations of p-tau181 (p=0.573), tau (p=0.456), Aβ42 (p=0.072), and ratios of Aβ42/40 (p=0.785) and tau/Aβ42 (p=0.335) were comparable between healthy controls and SCD patients.

Additionally, tau plasma concentrations in SCD patients showed no significant correlation with CSF concentrations of p-tau181 (p=0.171), tau (p=0.298) and Aβ42 (p=0.663) after controlling for confounders like educational level, gender and age.

Even between healthy controls with normal Aβ42 levels (≥600 pg/mL) and SCD patients with abnormal Aβ42 levels (<600 pg/mL), tau plasma levels were not significantly different (3.45 vs 3.29 pg/mL; p=0.654).

Tau plasma levels were also not significantly associated with CSF concentrations of Aβ42 (p=0.782), tau (p=0.142) and p-tau181 (p=0.436) in SCD patients with abnormal Aβ42 levels.

The study included 111 SCD patients and 134 cognitively healthy controls who were matched by age and gender. Participants were recruited from the DZNE longitudinal study on cognition and dementia, and were administered the Mini-Mental State Examination and Clinical Dementia Rating tests to assess cognitive status.

One-way analyses of covariance were used to determine the differences in cognitive status, and plasma and CSF biomarkers between healthy controls and SCD patients. Linear regression was used to determine relationships between biomarkers.

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Most Read Articles
Roshini Claire Anthony, 2 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

6 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
4 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
15 Sep 2017
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.