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Plasma ghrelin levels, G/O ratios low in elderly intestinal metaplasia patients

20 Apr 2017

Plasma ghrelin levels and plasma ghrelin/obestatin (G/O) ratios are significantly reduced in elderly intestinal metaplasia patients, a new study shows.

The investigators prospectively enrolled 92 elderly patients (median age, 69.4 [60 to 88]) diagnosed with functional dyspepsia (FD). Those currently receiving nonsteroidal anti-inflammatory drugs, below the age of 60, with histories of gastric surgery and with structural diseases were excluded.

Participants were divided into two according to the Rome III criteria: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Enzyme immunoassays and histological and histopathological examinations were performed to evaluateplasma ghrelin, plasma G/O and Heliobacter pylori infection.

Of the 92 patients, 49 tested positive for H. pylori; between the infection positive and negative groups, there were no significant differences in age, BMI, plasma ghrelin and obestatin levels, proportion of males, and symptoms and subtypes of FD.

Similarly, there were no significant differences in terms of age, proportion of males, BMI, plasma ghrelin and obestatin levels when participants were grouped according to FD subtype, presence of gastric atrophy and histopathological findings.

In contrast, patients with intestinal metaplasia had significantly lower levels of plasma ghrelin (6.59±0.29 pg/mL) and plasma G/O (1.78±0.54) than those without metaplasia (6.77±0.34 pg/mL and 2.17±0.92, respectively; p=0.01 and p=0.012, respectively).

Analysis according to gender showed that the association of intestinal metaplasia sand plasma ghrelin was stronger in males (p=0.008) than in females (p=0.325). On the other hand,the association between metaplasia and plasma G/O lost significance in both males (p=0.051) and females (p=0.086).

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
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