Most Read Articles
Jairia Dela Cruz, 22 days ago
Statins appear to have a dose-dependent association with the risk of tuberculosis (TB), with a nationwide population-based study showing that statin users have 47 percent lower incidence of TB compared with nonusers.
one month ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
Pearl Toh, 4 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.
6 days ago
Mesalazine is not superior to placebo in terms of preventing recurrence in patients with diverticulitis, according to data from two phase III trials.

Plasma ghrelin levels, G/O ratios low in elderly intestinal metaplasia patients

2 months ago

Plasma ghrelin levels and plasma ghrelin/obestatin (G/O) ratios are significantly reduced in elderly intestinal metaplasia patients, a new study shows.

The investigators prospectively enrolled 92 elderly patients (median age, 69.4 [60 to 88]) diagnosed with functional dyspepsia (FD). Those currently receiving nonsteroidal anti-inflammatory drugs, below the age of 60, with histories of gastric surgery and with structural diseases were excluded.

Participants were divided into two according to the Rome III criteria: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Enzyme immunoassays and histological and histopathological examinations were performed to evaluateplasma ghrelin, plasma G/O and Heliobacter pylori infection.

Of the 92 patients, 49 tested positive for H. pylori; between the infection positive and negative groups, there were no significant differences in age, BMI, plasma ghrelin and obestatin levels, proportion of males, and symptoms and subtypes of FD.

Similarly, there were no significant differences in terms of age, proportion of males, BMI, plasma ghrelin and obestatin levels when participants were grouped according to FD subtype, presence of gastric atrophy and histopathological findings.

In contrast, patients with intestinal metaplasia had significantly lower levels of plasma ghrelin (6.59±0.29 pg/mL) and plasma G/O (1.78±0.54) than those without metaplasia (6.77±0.34 pg/mL and 2.17±0.92, respectively; p=0.01 and p=0.012, respectively).

Analysis according to gender showed that the association of intestinal metaplasia sand plasma ghrelin was stronger in males (p=0.008) than in females (p=0.325). On the other hand,the association between metaplasia and plasma G/O lost significance in both males (p=0.051) and females (p=0.086).

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Most Read Articles
Jairia Dela Cruz, 22 days ago
Statins appear to have a dose-dependent association with the risk of tuberculosis (TB), with a nationwide population-based study showing that statin users have 47 percent lower incidence of TB compared with nonusers.
one month ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
Pearl Toh, 4 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.
6 days ago
Mesalazine is not superior to placebo in terms of preventing recurrence in patients with diverticulitis, according to data from two phase III trials.