Most Read Articles
Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 
Jairia Dela Cruz, 6 days ago
Naturalistic use of psychedelic drugs among marginalized women who are street-involved is independently related to reduced suicidality, whereas crystal methamphetamine use and childhood trauma signal a high risk of attempting suicide in this population, according to a study from Canada.
08 Oct 2017
Tumour necrosis factor inhibitors (TNFIs) may inhibit spinal radiographic progression in patients with ankylosing spondylitis (AS) through the inhibiting effect of the drugs on disease activity, a study suggests.

Piperaquine-resistant P. falciparum strains lessen response to artemisinin

28 Sep 2017

Emergent piperaquine-resistant strains of Plasmodium falciparum have reduced patient response to artemisinin producing nationwide treatment failure rates of more than 20 percent, a new study from Vietnam has shown.

The study included 489 uncomplicated P. falciparum malaria patients recruited from three provinces in southern Vietnam: Binh Phuoc, Ninh Thuan and Gia Lai. Of the patients, 95 percent (n=471) were febrile upon admission.

The highest treatment failure rates were reported in the Binh Phuoc province, with a failure rate of 0 percent in 2012 and 2013, 7 percent in 2014, and 26 percent in 2015. The increasing trend reached statistical significance (p<0.001).

In contrast, data from Ninh Thuan province showed only two failures of late treatment, while no treatment failures were reported for the Gia Lai province.

In Binh Phuoc province, median parasite clearance time increased from 63 hours in 2012 to 78 hours in both 2014 and 2015 (p=0.002 for trend). Similarly, median parasite clearance half-life increased significantly from 3.75 hours in 2012 to 6.60 hours in 2015 (p<0.001 for trend).

Median parasite clearance time also increased significantly in the Gia Lai province, jumping from 36 to 96 hours from 2011 to 2015 (p<0.001 for trend). Parasite clearance half-life also rose significantly from 1.97 to 6.88 hours, respectively (p<0.001 for trend).

In contrast, parasite clearance time (p=0.29) and parasite clearance half-life (p=0.29) did not show significant changes from 2013 to 2015 in Ninh Thuan province.

Additional ring stage assay of nine P. falciparum isolates collected in 2015 showed that all samples were resistant to dihydroartemisinin (DHA; survival rate >1). The median survival rate was 14.29 percent. Subsequent piperaquine survival assay also showed strong resistance to piperaquine (survival rate 10 percent; median survival rate 20.72 percent).

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Most Read Articles
Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 
Jairia Dela Cruz, 6 days ago
Naturalistic use of psychedelic drugs among marginalized women who are street-involved is independently related to reduced suicidality, whereas crystal methamphetamine use and childhood trauma signal a high risk of attempting suicide in this population, according to a study from Canada.
08 Oct 2017
Tumour necrosis factor inhibitors (TNFIs) may inhibit spinal radiographic progression in patients with ankylosing spondylitis (AS) through the inhibiting effect of the drugs on disease activity, a study suggests.