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Kavitha G. Shekar, 01 Mar 2016
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Use of phosphodiesterase type-5 (PDE5) inhibitors appears to reduce the risk of all-cause mortality among type 2 diabetes patients at high risk of cardiovascular disease (CVD), a study has shown.
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Persistent wetting in childhood tied to urinary incontinence in adolescence

17 Mar 2017

Persistent wetting during childhood is associated with increased nocturia, bedwetting, daytime wetting, passing hard stools and urgency in adolescence, a new study finds.

The study included 8,751 (4,244 females) children with parent-reported bedwetting and daytime wetting frequency data for at least three of five timepoints: 4, 5, 6, 7 and 9 years of age. Information on bladder and bowel symptoms at age 14 were collected from the participants themselves.

Low stool frequency, passing hard stools, frequent urination, voiding postponement, low voided volume, nocturia, daytime wetting, urgency and bedwetting at age 14 were the primary outcomes of the study.  Parallel longitudinal latent class analysis (LLCA) was performed to create models for daytime wetting and bedwetting.

Five distinct, clinically relevant classes of urinary incontinence were established: normative development of bladder control (n=5,513; 47.5 percent male), delayed attainment of bladder control (n=752; 52.9 percent male), bedwetting alone (n=1,365; 68.4 percent male), daytime wetting alone (n=508; 33.5 percent male) and persistent wetting(n=613; 63.0 percent male).

Those in the daytime wetting alone (odds ratio [OR], 10.1; 95 percent CI, 4.50 to 10.8), persistent wetting (OR, 6.98; 4.50 to 10.8) and delayed bladder control (OR, 4.84; 3.11 to 7.54) classes had increased odds of daytime wetting at 14 years old.

There was an increased chance of bedwetting at 14 years in children that belonged to the persistent wetting (OR, 23.5; 15.1 to 36.5), bedwetting alone (OR, 3.69; 2.21 to 6.17) and delayed bladder control (OR, 3.83; 2.10 to 6.99) groups.

There was also a greater chance of nocturia and urgency in the persistent wetting class (OR, 2.39; 1.79 to 3.20; OR, 2.10; 1.44 to 3.07, respectively). Those in the daytime wetting alone (OR, 2.17; 1.27 to 3.71) and persistent wetting (OR, 2.64; 1.63 to 4.27) classes had greater odds of passing hard stools in adolescence.

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Most Read Articles
Kavitha G. Shekar, 01 Mar 2016
Testosterone therapy may improve sexual function, enhance mood and reduce depressive symptoms in men ≤65 years, according to the testosterone trials (TTs). However, no improvement in vitality or walking distance was seen.
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According to the Singapore National Registry of Diseases Office (NRDO), prostate cancer is the third most common cancer and the sixth most common cause of cancer-related deaths affecting men in Singapore. Dr Daniel Tan, radiation oncologist and medical director of Asian American Radiation Oncology at Gleneagles Hospital, Singapore, speaks to Roshini Claire Anthony on the importance of early detection of prostate cancer and the challenges associated with diagnosing and treating this condition.