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PEG bowel preparations for colonoscopy mildly raise RGV

2 months ago

Bowel preparations with polyethylene glycol (PEG) slightly elevate residual gastric volume (RGV) but appear to have no clinical significance, according to a new study.

“Obstacles to high-volume bowel preparation by anaesthesia providers resulting from concerns over aspiration risk are common during colonoscopy,” researchers said.

To examine the RGV in colonoscopy after bowel preparations with 3-L PEG, the authors conducted prospective measurement of RGV in patients undergoing esophagogastroduodenoscopy (EGD) and morning colonoscopy with split-dose PEG preparation, patients undergoing EGD and afternoon colonoscopy with same-day PEG preparation, and patients undergoing EGD alone under moderate conscious sedation.

Consumption of clear liquids was permitted among colonoscopy patients until 2 hours before the procedure. Patients undergoing EGD alone were instructed not to eat or drink anything after midnight.

A total of 860 patients (n=330 in the split-dose preparation group; n=100 in the same-day preparation group; n=430 in the EGD-only group) were evaluated. Baseline demographics and disease/medication factors were similar.

Patients receiving the same-day preparation (35.4 mL or 0.56 mL/kg) had a significantly higher mean RGV than those receiving the split-dose preparation (28.5 mL or 0.45 mL/kg; p=0.023) and those undergoing EGD alone (22.8 mL or 0.36 mL/kg; p<0.0001)

Within the bowel-preparation groups, RGV was similar between patients with fasting times of 2 to 3 hours and those with fasting times >3 hours. All three groups had similar distribution shape and RGV range. There was no aspiration in any group.

These findings support the current fasting guidelines for colonoscopy, according to researchers.

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Elvira Manzano, one year ago
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one year ago
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Microbes are strongly associated with metabolic syndrome. Conversely, however, the microbiome also potentially holds the key to health solutions, says an expert.
one year ago
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