Most Read Articles
Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

PDUS-detected synovitis predicts short-term flares in PsA patients in remission

25 Jul 2017
As opposed to the 2% global prevalence, psoriasis affects 0.3% to 0.6% of the Hong Kong population.

Power Doppler ultrasound (PDUS)-detected synovitis strongly predicts short-term flares among patients with psoriatic arthritis (PsA) in clinical remission, reports a new study.

To assess PDUS features at joint level and to assess its value for predicting short-term flares, the investigators followed consecutive patients with PsA in clinical remission according to the attending rheumatologist and who fulfilled minimal disease activity criteria and/or 28-joint Disease Activity Score in remission criteria for 6 months. All patients underwent PDUS examination of 18 joints.

Disease flare referred to any increase in disease activity generating the need for any of the following changes in therapy with disease-modifying antirheumatic drugs (DMARD) by the attending rheumatologist: dose increase, switch or addition of a different DMARD, and/or switch or addition of biological therapies.

There were 54 patients with PsA in clinical remission, of which 15 (27.8 percent) had a flare within the next 6 months. A total of 20 patients had at least one joint with PDUS synovitis at baseline; of these, 13 (65 percent) had a disease flare during the follow-up period compared with only two of the 34 patients (5.9 percent) without baseline PDUS synovitis (relative risk, 11; 95 percent CI, 2.8 to 44; p<0.001).

Logistic regression analysis revealed that the only variables associated with short-term flares were baseline PDUS synovitis and the use of nonbiologic DMARD.

According to researchers, “PDUS has been shown to detect subclinical synovitis in PsA, but its value is not yet fully understood.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.