Most Read Articles
5 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 6 days ago
An 8-week regimen of sofosbuvir-velpatasvir-voxilaprevir combination is not noninferior to a 12-week regimen of sofosbuvir-velpatasvir for patients with chronic hepatitis C virus (HCV) infection, report two recent phase 3 open-label trials.
2 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
5 days ago
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.

Patients with sarcomatoid renal cell carcinoma face poor prognosis despite targeted therapy

30 Aug 2017

Despite treatment with nephrectomy and systemic therapy in the cytokine and targeted therapy eras, overall survival and prognosis remain poor among patients with sarcomatoid renal cell carcinoma, with no clear long-term benefit of targeted therapy, according to a recent study.

Researchers conducted a retrospective study of patients with sarcomatoid renal cell carcinoma who underwent nephrectomy and received systemic therapy at a centre in the cytokine era (1987 to 2005) or the targeted therapy era (2006 to 2015). They used multivariate regression models to determine the association of covariables with survival.

A total of 167 (83.9 percent) out of 199 patients with sarcomatoid renal cell carcinoma died (median overall survival, 16.5 months; 95 percent CI, 15.2 to 20.9).

Patients with clear cell histology had significantly longer survival compared with those with nonclear cell histology (p=0.034). Survival was significantly shorter in patients with synchronous metastatic disease than in those with metachronous metastatic disease (median, 12.1 vs 23.3 months; p=0.0064).

Furthermore, the presence of sarcomatoid features can be detected by biopsy of the primary tumours or a metastatic site in only 7.5 percent of cases.

There was a significant improvement in survival rate seen in the first year in patients treated in the targeted therapy era (p=0.011), but this effect was attenuated at year 2, disappeared at years 3 to 5 after diagnosis, and was not evident in patients with poor risk features.

“This underscores the need to develop more effective systemic therapies for these patients,” according to researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
5 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 6 days ago
An 8-week regimen of sofosbuvir-velpatasvir-voxilaprevir combination is not noninferior to a 12-week regimen of sofosbuvir-velpatasvir for patients with chronic hepatitis C virus (HCV) infection, report two recent phase 3 open-label trials.
2 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
5 days ago
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.