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Elvira Manzano, Yesterday
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Patients with psoriasis more likely to commit suicide

13 Sep 2017

The likelihood of suicidal ideation, suicide attempts and completed suicides is substantially greater in patients with psoriasis, according to a recent study. Among these patients, those who are younger and whose psoriasis is more severe are at risk of suicidality.

Researchers conducted a systematic review and meta-analysis to further understand the relationship between psoriasis and suicidality. The databases of PubMed, Embase, PsycINFO and Cochrane were systematically searched for literature published between 1946 and 2017.

A total of 18 studies were included. This involved 1,767,583 participants, of whom 330,207 had psoriasis.

Based on random effects modelling, suicidal ideation among patients with psoriasis had a pooled odds ratio (OR) of 2.05 (95 percent CI, 1.54 to 2.74). These patients were more likely to attempt suicides (OR, 1.32; 1.14 to 1.54) and complete suicide (OR, 1.20; 1.04 to 1.39) than those without psoriasis.

The factors associated with higher possibility of suicidality were younger age and more severe psoriasis.

“There are few studies examining suicidality in conjunction with psoriasis severity,” researchers said.

In another study, Chi and colleagues found no association between psoriasis and suicidal thought and behaviour. They found no increase in the risk of suicide (risk ratio [RR], 1.13; 0.87 to 1.46), suicide attempt (RR, 1.25; 0.89 to 1.75) or suicidality (RR, 1.26; 0.97 to 1.64) among patients with psoriasis. Their stratified analysis also revealed no increase in suicide, suicide attempt and suicidality among those with either mild or severe psoriasis. [Am J Clin Dermatol 2017;doi:10.1007/s40257-017-0281-1]

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Most Read Articles
Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.