Most Read Articles
Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Patients with cancer face heightened short-term risk of arterial thromboembolism

25 Aug 2017

There is a markedly increased short-term risk of arterial thromboembolism among patients with incident cancer, a recent study has found.

To improve understanding of the epidemiological relationship between arterial thromboembolism and cancer, researchers identified patients with a new primary diagnosis of breast, lung, prostate, colorectal, bladder, pancreatic or gastric cancer or non-Hodgkin lymphoma from 2002 to 2011 using the Surveillance Epidemiology and End Results–Medicare linked database.

The authors individually matched patients by demographics and comorbidities to a Medicare enrolee without cancer, and followed each pair through 2012.

Arterial thromboembolism, defined as myocardial infarction or ischaemic stroke, was identified using validated diagnosis codes. Competing risk survival statistics was used to calculate cumulative incidence rates. Cox hazards analysis was performed to compare rates between groups at discrete time points.

In total, 279,719 pairs of patients with cancer and matched controls were included. Patients with cancer had higher 6-month cumulative incidence of arterial thromboembolism than controls (4.7 percent; 95 percent CI, 4.6 to 4.8 percent vs 2.2 percent; 2.1 to 2.2 percent; hazard ratio [HR], 2.2; 2.1 to 2.3).

The 6-month cumulative incidence of myocardial infarction was 2.0 percent (1.9 to 2.0 percent) vs 0.7 (0.6 to 0.7 percent) in patients with cancer and control patients, respectively (HR, 2.9; 2.8 to 3.1). The 6-month cumulative incidence of ischaemic stroke was 3.0 percent (2.9 to 3.1 percent) in patients with cancer vs 1.6 percent (1.6 to 1.7 percent) in controls (HR, 1.9; 1.8 to 2.0).

Excess risk varied by cancer type (highest for lung), was associated with cancer stage and had largely resolved by 1 year, according to researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.