Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Patient-reported outcomes hardly predict RA change in disease activity

06 Sep 2017

It appears that patient-reported pain, stiffness and fatigue at baseline offer limited value for the prediction of changes in disease activity and activity limitation in early rheumatoid arthritis (RA), according to a recent study.

Researchers recruited cases (n=1,415) to the Yorkshire Earl Arthritis Register between 1997 and 2009 to evaluate patient-reported variables as predictors of change in disease activity and disability in RA. Multilevel models were used to identify Predictors of the 28-joint Disease Activity Score (DAS28) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) at baseline and change over 12 months.

The baseline predictors were the following: age, sex, symptom duration, autoantibody status, pain and fatigue visual analogue scales (VAS), DAS28, HAQ-DI, and duration of early morning stiffness (EMS).

Women had slower rates of change than men: DAS28 dropped by 0.19 and 0.17 units/month, and HAQ-DI by 0.028 and 0.023 units/month in men and women, respectively. The effects of baseline pain and EMS on rates of change were small, while fatigue VAS was only associated with DAS28 and HAQ-DI at baseline.

In patients recruited up to 2002, those with greater pain at baseline reduced DAS28 more quickly (by 0.01 unites/month of DAS28 per cm pain VAS; p=0.024). In patients recruited after 2002, there was a stronger effect for pain (by 0.01 units/month; 0.087).

Reduction in DAS28 was greater with longer EMS. In both cohorts, patients with longer EMS duration had greater reduction in HAQ-DI (p=0.006). However, pain and fatigue were not significant predictors of change in HAQ-DI, according to researchers.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.