Most Read Articles
14 Jan 2016
Tocotrienols are one of the two classes of compounds generally known as vitamin E. Prominent researcher in pharmaceutical technology, Professor Yuen Kah Hay, recently spoke to MIMS Doctor about the neuroprotective benefits conferred by palm tocotrienols. He shared key insights from a clinical trial performed by his team and about the compound’s potential for clinical use.
19 Feb 2017
There appears to be no association between Toxoplasma gondii and Parkinson’s disease, although exposure to T. gondii may have an effect on specific types of Parkinson’s disease, according to a recent study.
Dr. Angela V. Ignacio, 23 Feb 2017
The use of mirror therapy appears to be effective in treating left visual hemineglect in stroke patients and may be combined with transcutaneous electrical nerve stimulation (TENS) for rehabilitation management in this population, according to a study presented at the 7th Association of South-East Asian Pain Societies Congress (ASEAPS 2017) held in Yangon, Myanmar.

Parkinson’s disease, essential tremor impair cognitive performance

15 May 2017

Both Parkinson’s disease (PD) and essential tremor (ET) negatively influence cognitive performance even in the absence of dementia, with PD showing a greater effect than ET, according to a study. Furthermore, while the deficits are in many of the same cognitive domains, the affected domains do not completely overlap.

The study used data from the NEDICES study involving 2,438 individuals without dementia who went through a short neuropsychological battery test. Nonparametric techniques were applied to assess for differences in and/or a gradient of impairment across the three patient groups: PD (n=46), ET (n=180) and healthy controls (n=2,212). A head-to-head comparison of cognitive performance in PD and ET were also performed, with adjustments made for the confounding effects of age and education.

Compared with controls, PD and ET patients had poorer cognition. There was a notable gradient of performance impairment, such that the PD group performed poorly than the ET group and then each of these groups performed worse than controls. This gradient was observed in memory (p<0.05) and verbal fluency (p<0.001) tasks.

When the PD and ET groups were compared, the former had poorer scores in verbal fluency (p<0.05), whereas the latter had a poorer cognitive processing speed (p<0.05).

The present data have the potential to add value to the differential diagnosis, prognosis and management of movement disorders, researchers said.

Patients with PD and ET are at a greater risk of cognitive impairment compared with age- and education-matched healthy individuals. Both conditions show a pattern of dysfunction labelled as that of a fronto-subcortical type, with deficits in domains including attention, verbal fluency and memory being seen at early stages. Cognitive impairment has been associated with degeneration of cortical association areas in PD, whereas the neuropathological correlates of impairment in ET have not been completely elucidated. [J Neurol Sci 2011;310:176–182; Mov Disord 2014;29:694–703; Neurology 2013;81:60–66; Parkinsonism Relat Disord 2014;20:655–658]

Editor's Recommendations
Most Read Articles
14 Jan 2016
Tocotrienols are one of the two classes of compounds generally known as vitamin E. Prominent researcher in pharmaceutical technology, Professor Yuen Kah Hay, recently spoke to MIMS Doctor about the neuroprotective benefits conferred by palm tocotrienols. He shared key insights from a clinical trial performed by his team and about the compound’s potential for clinical use.
19 Feb 2017
There appears to be no association between Toxoplasma gondii and Parkinson’s disease, although exposure to T. gondii may have an effect on specific types of Parkinson’s disease, according to a recent study.
Dr. Angela V. Ignacio, 23 Feb 2017
The use of mirror therapy appears to be effective in treating left visual hemineglect in stroke patients and may be combined with transcutaneous electrical nerve stimulation (TENS) for rehabilitation management in this population, according to a study presented at the 7th Association of South-East Asian Pain Societies Congress (ASEAPS 2017) held in Yangon, Myanmar.