Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Palliative care improves outcomes in advanced HF patients

18 Jul 2017
Appropriate policies are required to facilitate and integrate palliative care in healthcare systems, and finance proper training for developing human resources.

Patients with advanced heart failure (HF) who undergo an interdisciplinary palliative care intervention (PAL) have consistently higher benefits in terms of quality of life (QoL), anxiety, depression and spiritual well-being compared with usual care (UC) alone, a recent study has found.

To assess whether an interdisciplinary PAL in addition to evidence-based HF care improves certain outcomes, researchers randomly assigned 150 patients with advanced HF between 15 August 2012 and 25 June 2015 to UC (n=75) or UC plus PAL (n=75) at a single centre.

Two QoL measurements, the Kansas City Cardiomyopathy Questionnaire (KCCQ) overall summary and the Functional Assessment of Chronic Illness Therapy–Palliative Care scale (FACIT–Pal), assessed at 6 months were the primary endpoints.

Secondary endpoints included evaluations of depression and anxiety (measured via the Hospital Anxiety and Depression Scale [HADS]), spiritual well-being (measured via the FACIT–Spiritual Well-Being scale [FACIT–Sp]), hospitalizations and mortality.

Patients assigned to UC + PAL exhibited clinically significant incremental improvement in KCCQ and FACIT-Pal scores from randomization to 6 months compared with UC alone (KCCQ difference, 9.49 points; 95 percent CI, 0.94 to 18.05; p=0.030; PACIT‒Pal difference, 11.77; 0.84 to 22.71; p=0.035).

Both depression (HADS-depression difference, −1.94 points; p=0.020) and anxiety (HADS-anxiety difference, −1.83 points; p=0.048) improved in UC + PAL patients compared with UC-alone patients. UC + PAL patients had also improved spiritual well-being vs UC-alone patients (FACIT–Sp difference, 3.98 points; p=0.027).

Neither rehospitalization nor mortality was affected by randomization to UC + PAL.

“Advanced HF is characterized by high morbidity and mortality,” researchers said. “Conventional therapy may not sufficiently reduce patient suffering and maximize QoL.”

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.