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Elvira Manzano, 4 days ago
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Pain, fatigue are most critical outcomes for patients receiving PsA treatment

11 Oct 2017

The most important outcomes for patients receiving treatment for psoriatic arthritis (PsA) are pain and fatigue, which are not well represented within existing composite measures, suggests a recent study.

Researchers conducted seven nominal group technique (NGT) meetings at four hospital sites to rank outcomes identified as important to patients with PsA and examine their representation in existing composite outcomes. They carried out two sorting rounds to generate a shortlist of outcomes followed by a group discussion and final ranking.

Patients received 15 points each in the final ranking round and then ranked their top five outcomes from the shortlist. The totals were summed across the seven NGT groups and were presented as a percentage of the maximum possible priority score.

A total of 31 patients (mean age 54 years; range, 24 to 77 years; 16 men) participated in the study. The mean disease duration was 10.3 years (range, 1 to 40) and mean Health Assessment Questionnaire was 1.15 (range, 0 to 2.63).

Patients ranked pain (93 points; 20.0 percent) as the highest outcome that they wished to see from treatment. This was followed by fatigue (62 points; 13.3 percent), physical fitness (33 points; 7.1 percent), halting/slowing damage (32 points; 6.9 percent) and quality of life/well-being (29 points; 6.2 percent).

After reviewing existing composite measures for PsA, there was no single measure that adequately identified all these outcomes.

“Future work will focus on validating composite measures modified to identify outcomes important to patients,” researchers said.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.