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Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

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Ovarian lipid metabolism modulates circulating premenopausal lipids

17 Sep 2017

Ovarian lipid metabolism and other previously unappreciated factors appear to contribute to the lipid profile in premenopausal women, a recent study has found.

A significant association existed between oestradiol and increased levels of high-density lipoprotein (HDL) cholesterol throughout the menstrual cycle and in the follicular phase. Ovarian effects correlated with reduced lipid levels, particularly during the luteal phase. Furthermore, oral contraceptive (OC) was associated with an increased total cholesterol to HDL cholesterol ratio and triglycerides.

Researchers conducted an experimental crossover with repeated measures in academic hospitals involving eight healthy, regularly menstruating women to assess how oestradiol, progesterone and ovarian lipid metabolism contributed to the premenopausal lipid profile, and to evaluate the acute effects of a common hormonal OC on circulating lipids,

Participants underwent periodic serum sampling during a normal menstrual cycle; a standard 21-day, monophasic combined hormonal OC cycle (30 µg of ethinyl oestradiol and 150 µg of levonorgestrel/day); menopause simulated by leuprolide acetate (22.5-mg depot); and an artificial menstrual cycle achieved via transdermal oestradiol (50 to 300 µg/day) and vaginal micronized progesterone (100 to 300 mg/day).

Evaluation of total cholesterol, HDL cholesterol, low-density lipoprotein cholesterol, triglycerides and the total cholesterol-to-HDL cholesterol ratio were the primary outcomes. All specimens except from the OC cycle were analysed to estimate the effect of oestradiol, progesterone and ovarian lipid metabolism. Researchers conducted subgroup analysis on the follicular and luteal phases. In a separate analysis, they assessed the effect of the OC in relation to the normal menstrual cycle.

The findings demonstrated the association of premenopausal circulating lipid profile with hormonal profile and ovarian lipid metabolism, according to researchers.

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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 4 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
6 days ago
Blood glucose testing every other day in patients with controlled gestational diabetes mellitus (GDM) resulted in higher testing compliance than every day testing, a new study has shown.