Most Read Articles
Pearl Toh, 7 days ago
Mepolizumab added on to standard of care for patients with severe eosinophilic asthma better improves health-related quality of life (HRQOL), along with improved asthma symptoms and lung function compared with placebo, according to the MUSCA* study.
Pearl Toh, 6 days ago
Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
5 days ago
Blood pressure (BP) ≥140/90 mm Hg appears to increase the risk of maternal complications and adverse foetal outcomes, irrespective of the number of medications used, a study suggests. However, the greatest risk is observed among pregnant women taking multiple agents and whose BP levels are within the aforementioned range.
7 days ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.

One-step SLK for polycystic disease is safe, feasible

one month ago

Simultaneous liver and kidney transplantations (SLK) in polycystic diseases carried out through a one-step midline approach is effective, feasible, safe and may help avoid pre-transplant renal replacement therapy, a new study shows.

The study included 12 polycystic disease patients undergoing one-step SLK by midline laparotomy. Follow-up data including postoperative complications were evaluated against the 24 patients who received the classical two-step SLK.

The one-step SLK was carried out through a xiphopubic incision of the abdomen. Access to liver, native kidney and iliac fossae was achieved through bilateral cephalad retraction of the ribcage and lateral retraction of the abdominal wall.

The median follow-up for the 12 patients who received the midline laparotomy was 373 (120 to 684) days. Of these, 8 were performed with a bilateral nephrectomy and 4 with unilateral nephrectomy. No complications were recorded.

Between those who received one-step and two-step SLK, there were no statistically significant differences in donor and recipient body mass index, age and gender distribution, Model of End Stage Liver Disease scores and preoperative need for blood product transfusion.

All patients showed good signs of recovery and transplants were observed to function immediately. There was no significant difference in surgical complications within 90 days between the one-step and two-step SLK groups.

Finally, patient and graft outcomes and length of stay in the intensive care unit were not significantly different between the two groups. Two deaths were recorded in the two-step SLK group.

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Most Read Articles
Pearl Toh, 7 days ago
Mepolizumab added on to standard of care for patients with severe eosinophilic asthma better improves health-related quality of life (HRQOL), along with improved asthma symptoms and lung function compared with placebo, according to the MUSCA* study.
Pearl Toh, 6 days ago
Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
5 days ago
Blood pressure (BP) ≥140/90 mm Hg appears to increase the risk of maternal complications and adverse foetal outcomes, irrespective of the number of medications used, a study suggests. However, the greatest risk is observed among pregnant women taking multiple agents and whose BP levels are within the aforementioned range.
7 days ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.