Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

One-step SLK for polycystic disease is safe, feasible

25 Mar 2017

Simultaneous liver and kidney transplantations (SLK) in polycystic diseases carried out through a one-step midline approach is effective, feasible, safe and may help avoid pre-transplant renal replacement therapy, a new study shows.

The study included 12 polycystic disease patients undergoing one-step SLK by midline laparotomy. Follow-up data including postoperative complications were evaluated against the 24 patients who received the classical two-step SLK.

The one-step SLK was carried out through a xiphopubic incision of the abdomen. Access to liver, native kidney and iliac fossae was achieved through bilateral cephalad retraction of the ribcage and lateral retraction of the abdominal wall.

The median follow-up for the 12 patients who received the midline laparotomy was 373 (120 to 684) days. Of these, 8 were performed with a bilateral nephrectomy and 4 with unilateral nephrectomy. No complications were recorded.

Between those who received one-step and two-step SLK, there were no statistically significant differences in donor and recipient body mass index, age and gender distribution, Model of End Stage Liver Disease scores and preoperative need for blood product transfusion.

All patients showed good signs of recovery and transplants were observed to function immediately. There was no significant difference in surgical complications within 90 days between the one-step and two-step SLK groups.

Finally, patient and graft outcomes and length of stay in the intensive care unit were not significantly different between the two groups. Two deaths were recorded in the two-step SLK group.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.