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Roshini Claire Anthony, 16 Oct 2017

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

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Old age, comorbidities up risk of dying after severe hypoglycaemia in SG

Pearl Toh
07 Oct 2017

Older age, presence of multiple comorbidities, and longer length of hospital stay, rather than difference in glycaemic control, were associated with an increased risk of 1-year death following admission with severe hypoglycaemia in patients with diabetes, according to a Singapore study.

The retrospective observational study included 311 patients with diabetes (mean age 70.7 years) who were admitted to hospital after being diagnosed with severe hypoglycaemia at the emergency department of Singapore General Hospital. A total of 70 deaths (22.5 percent) were recorded within 1 year of admission. [EASD 2017, abstract 730]

Compared with patients who lived longer than 1 year after hospitalization for severe hypoglycaemia, those who died within a year were older (69.2 vs 75.3 years; p<0.05) and had more comorbidities as assessed by CCI* (mean score, 4.1 vs 6.0; p<0.05). Patients who died within a year following admission also tended to stay longer in the hospital (10 vs 5 days; p<0.05).

Among the three factors, CCI score was associated with the highest risk of dying within 1 year after admission, followed by age, and length of hospital stay (hazard ratios, 1.57; p<0.001, 1.06; p=0.01, and 1.05; p=0.01, respectively).

In addition, deceased patients had a lower albumin count on admission (30.3 vs 36.2 g/L; p<0.05) and were more likely to have impaired creatinine clearance at <30 mL/min (65.7 percent vs 35.7 percent; p=0.01) compared with those who survived beyond 1 year.

However, levels of HbA1c were not significantly different between survivors and deceased patients (mean, 7.0 percent vs 6.7 percent; p>0.05).

“The high 1 year mortality rate highlighted the vulnerabilities of certain individuals to adverse outcomes,” according to the researchers led by Dr Teh Ming Ming from the Department of Endocrinology in Singapore General Hospital.

“Hence, admission with severe hypoglycaemia has important prognostic implications … [as it] offers the window of opportunity for healthcare professionals to intervene by comprehensively addressing the issue of hypoglycaemia and other health issues especially in the high-risk group of patients,” said Teh and co-authors.

Nonetheless, the researchers also acknowledged that whether hypoglycaemia causes death in the short term could not be determined based on the current data set.    

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Most Read Articles
Roshini Claire Anthony, 16 Oct 2017

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.