Most Read Articles
Roshini Claire Anthony, 28 Sep 2015

Individuals with chronic ischaemic heart disease (IHD) and a small left ventricle and thick myocardium demonstrated higher levels of cardiac remodelling as opposed to those with a large ventricle and thin myocardium, contrary to the prevailing understanding, according to the DOPPLER-CIP study. 

18 Aug 2016
Chronic kidney disease (CKD), regardless of the stage, appears to have no direct effect on cardiovascular mortality within 180 days and 2 years from digoxin treatment initiation in treatment-naïve patients with non-valvular atrial fibrillation (AF), a Danish cohort study suggests.
2 days ago
The presence of target organ damage (TOD) in hypertension is more likely to result in blood pressure (BP) elevation, independently of the type of measurement (office or ambulatory, central or peripheral), according to a recent study. Central BP, even monitored during 24 hours, is not better correlated with TOD than peripheral BP.
09 Nov 2016
Ischaemic conditioning has no overall effect on the mortality risk in people undergoing invasive procedures, and its possible effects on stroke and acute kidney injury remain unknown given methodological concerns and low event rates, according to a systematic review and meta-analysis.

Occupational PAH exposure ups risk of cardiovascular disease

13 Sep 2017
An Indian doctor has been awarded a SGD3 million grant to further study cardiovascular diseases.

Occupational exposure to polycyclic aromatic hydrocarbons (PAH) leads to higher levels of cardiovascular disease (CVD) risk markers, a recent study has shown.

Compared with the 152 controls (median age 43 years), chimney sweeps (n=151; median age 43 years) had significantly higher levels of exposure to the PAHs 1-hydroxypyrene (1-OH-PYR), 3-hydroxybenzo[a]pyrene (3-OH-BaP), 2-hydroxyphenanthrene (2-OH-PH) and 3-hydrxoybenzo[a]anthracene (3-OH-BaA; p<0.001 for all) even after controlling for age, smoking and BMI.

Specifically, the gravity-adjusted concentration of 1-OH-PYR was seven times higher in chimney sweeps than in controls. Values were four times higher for 2-OH-PH and three times higher for both 3-OH-BaP and 3-OH-BaA.

Levels of homocysteine (p≤0.001), high-density lipoprotein (HDL; p≤0.004) and cholesterol (p≤0.01) were all significantly elevated in chimney sweeps compared with healthy controls, according to the general linear models. Levels of triglycerides and low-density lipoproteins were higher but did not reach statistical significance.

In the final model, adjusted for all possible confounders such as smoking status and exposure to PAH from hobbies, only the association between 2-OH-PH and diastolic blood pressure remained statistically significant (β, 1.72; 95 percent CI, 0.66 to 2.78; p=0.002).

Chimney sweeps were recruited from 29 different companies across Sweden and usually performed soot sweeping, white sweeping and office work. Controls were employees from other companies and were not routinely expose to PAH.

Urine samples were collected from the participants and subjected to liquid chromatography coupled with mass spectrometry to measure PAH metabolite levels in urine. On the other hand, CVD markers were measured from serum samples.

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Most Read Articles
Roshini Claire Anthony, 28 Sep 2015

Individuals with chronic ischaemic heart disease (IHD) and a small left ventricle and thick myocardium demonstrated higher levels of cardiac remodelling as opposed to those with a large ventricle and thin myocardium, contrary to the prevailing understanding, according to the DOPPLER-CIP study. 

18 Aug 2016
Chronic kidney disease (CKD), regardless of the stage, appears to have no direct effect on cardiovascular mortality within 180 days and 2 years from digoxin treatment initiation in treatment-naïve patients with non-valvular atrial fibrillation (AF), a Danish cohort study suggests.
2 days ago
The presence of target organ damage (TOD) in hypertension is more likely to result in blood pressure (BP) elevation, independently of the type of measurement (office or ambulatory, central or peripheral), according to a recent study. Central BP, even monitored during 24 hours, is not better correlated with TOD than peripheral BP.
09 Nov 2016
Ischaemic conditioning has no overall effect on the mortality risk in people undergoing invasive procedures, and its possible effects on stroke and acute kidney injury remain unknown given methodological concerns and low event rates, according to a systematic review and meta-analysis.