Most Read Articles
Angeline Woon, 01 Jan 2014

The criteria for systemic sclerosis have been updated, and the 2013 disease classification is an improvement on the 1980 version.

15 Jun 2017
Telomeres appear to be shorter in patients with gout than in healthy individuals, indicating increased cellular senescence, according to a study. In gout, telomere shortening is associated with flare frequency and cardiovascular (CV) disease.
Kavitha G. Shekar, 14 Jun 2016
The incidence of type 1 diabetes mellitus (T1D) was found to be higher in juvenile idiopathic arthritis patients (JIA) compared with the general population, said German researchers at the European League Against Rheumatism Annual Congress (EULAR 2016) held in London, UK.
27 Mar 2017
Obese individuals suffering from knee pain maintain more knee flexion during gait and use a hyper-extended knee posture while standing, a new study shows.

Obesity potentially linked to higher CRP, ESR levels in women with RA

Elaine Soliven
19 Apr 2017

Obesity appears to be associated with increased levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in women with rheumatoid arthritis (RA), according to a recent study.

“CRP and ESR are routinely used in the diagnosis and assessment of disease activity in patients with RA ... higher levels of CRP have been shown to be associated with greater body mass index (BMI) and adiposity, especially among women,” according to the researchers.

Data from the BC* and VARA** cohorts (women with RA, n=451 and 1,652, respectively) were compared with the NHANES*** and NHANES I cohorts (general population adults, n=10,813 and n=12,227, respectively). [Arthritis Care and Researcher 2017;doi.org/10.1002/acr.23229]

After adjusting for age, race, and smoking status, CRP was associated with BMI across the evaluated cohorts (β=0.057, 95 percent confidence interval [CI], 0.035–0.080; p<0.001 in BC, β=0.030, 95 percent CI, 0.014–0.045; p<0.001 in VARA, and β=0.097, 95 percent CI, 0.092–0.101; p<0.001 in NHANES), with significantly higher levels in severely obese women (≥35 kg/m2, p<0.001).

ESR was also associated with BMI across the evaluated cohorts (β=0.020, 95 percent CI, 0.016–0.024; p<0.001 in NHANES I), but with significantly higher levels in severely obese women in the two RA cohorts (β=0.033, 95 percent CI, 0.010–0.057; p<0.006 in BC and β=0.016, 95 percent CI, -0.001 to 0.032; p<0.051 in VARA).

CRP and ESR were also associated with fat mass (FMI Z-score, β=0.52, 95 percent CI, 0.35–0.69; p<0.001 and β=-0.20, 95 percent CI, 0.01–0.40; p<0.05, respectively) but not lean mass (ALMI Z-score, β=-0.18, 95 percent CI, -0.36 to -0.01; p<0.05 and β=-0.01, 95 percent CI, -0.24 to 0.23, respectively).

The findings were consistent with a previous study that demonstrated an association between adiposity and CRP levels in women with RA. [Arthritis Rheum 2008;58:2632-2641]

“BMI is an imperfect measure of adiposity, especially in RA … and as shown in this study, is also highly associated with inflammatory markers in women with RA,” said the researchers.

Despite the large sample sizes, the researchers acknowledged that data from the two RA cohorts was insufficient to estimate results. “Disease activity and ESR were also not measured in all studies or at all study observations, reducing power in these analyses,” they said.


*BC: Body Composition cohort
**VARA: Veterans Affairs Rheumatoid Arthritis registry
***NHANES: National Health and Nutrition Examination Survey

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Angeline Woon, 01 Jan 2014

The criteria for systemic sclerosis have been updated, and the 2013 disease classification is an improvement on the 1980 version.

15 Jun 2017
Telomeres appear to be shorter in patients with gout than in healthy individuals, indicating increased cellular senescence, according to a study. In gout, telomere shortening is associated with flare frequency and cardiovascular (CV) disease.
Kavitha G. Shekar, 14 Jun 2016
The incidence of type 1 diabetes mellitus (T1D) was found to be higher in juvenile idiopathic arthritis patients (JIA) compared with the general population, said German researchers at the European League Against Rheumatism Annual Congress (EULAR 2016) held in London, UK.
27 Mar 2017
Obese individuals suffering from knee pain maintain more knee flexion during gait and use a hyper-extended knee posture while standing, a new study shows.