Most Read Articles
Roshini Claire Anthony, 28 Sep 2015

Individuals with chronic ischaemic heart disease (IHD) and a small left ventricle and thick myocardium demonstrated higher levels of cardiac remodelling as opposed to those with a large ventricle and thin myocardium, contrary to the prevailing understanding, according to the DOPPLER-CIP study. 

18 Aug 2016
Chronic kidney disease (CKD), regardless of the stage, appears to have no direct effect on cardiovascular mortality within 180 days and 2 years from digoxin treatment initiation in treatment-naïve patients with non-valvular atrial fibrillation (AF), a Danish cohort study suggests.
2 days ago
The presence of target organ damage (TOD) in hypertension is more likely to result in blood pressure (BP) elevation, independently of the type of measurement (office or ambulatory, central or peripheral), according to a recent study. Central BP, even monitored during 24 hours, is not better correlated with TOD than peripheral BP.
09 Nov 2016
Ischaemic conditioning has no overall effect on the mortality risk in people undergoing invasive procedures, and its possible effects on stroke and acute kidney injury remain unknown given methodological concerns and low event rates, according to a systematic review and meta-analysis.

Obesity, underweight in youth linked to adverse cardiac surgery outcomes

14 Sep 2017

Children, adolescents and young adults who are obese, underweight or severely underweight face an increased risk of composite adverse cardiac surgery outcome of death, major adverse event and/or wound infection, independent of other risk factors, a study has found.

The multicentre retrospective cohort study included 18,337 patients aged 10 to 35 years scheduled to undergo a congenital heart disease operation between January 2010 and December 2015. Operative mortality and a composite outcome (operative mortality, major adverse event, prolonged hospital length of stay and wound infection/dehiscence) were the primary endpoints.

Multivariate logistic regression analysis was performed to test the associations between age-/sex-adjusted body mass index (BMI) percentiles and the outcomes, with adjustment for patient-level risk factors.

Of the patients, 16 percent were obese, 15 percent overweight, 53 percent normal weight, 7 percent underweight and 9 percent severely underweight. The greatest risks of operative mortality (p=0.04) and composite outcome (p<0.0001) were observed among severely underweight and obese patients. Severely underweight BMI increased the likelihood of unplanned cardiac operation and reoperation for bleeding, whereas obesity increased the risk of wound infection.

On multivariable analysis, the risk of composite outcome was notably elevated in obese (odds ratio [OR], 1.28; p=0.008), severely underweight (OR, 1.29; p<0.0001) and underweight patients (OR, 1.39; p=0.002). However, the association between BMI and operative mortality was no longer significant.

The study underscores that there are significant associations between body composition and perioperative outcome after congenital heart surgery, which may not be otherwise explained by patient and procedure factors, according to researchers.

Further studies are warranted to elucidate the mechanisms underlying the observed associations, researchers said, adding that interventions aimed at improving nutrition in underweight patients and weight loss in obese subjects need to be studied both for their efficacy in affecting BMI and effect on cardiac surgery outcome.

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Most Read Articles
Roshini Claire Anthony, 28 Sep 2015

Individuals with chronic ischaemic heart disease (IHD) and a small left ventricle and thick myocardium demonstrated higher levels of cardiac remodelling as opposed to those with a large ventricle and thin myocardium, contrary to the prevailing understanding, according to the DOPPLER-CIP study. 

18 Aug 2016
Chronic kidney disease (CKD), regardless of the stage, appears to have no direct effect on cardiovascular mortality within 180 days and 2 years from digoxin treatment initiation in treatment-naïve patients with non-valvular atrial fibrillation (AF), a Danish cohort study suggests.
2 days ago
The presence of target organ damage (TOD) in hypertension is more likely to result in blood pressure (BP) elevation, independently of the type of measurement (office or ambulatory, central or peripheral), according to a recent study. Central BP, even monitored during 24 hours, is not better correlated with TOD than peripheral BP.
09 Nov 2016
Ischaemic conditioning has no overall effect on the mortality risk in people undergoing invasive procedures, and its possible effects on stroke and acute kidney injury remain unknown given methodological concerns and low event rates, according to a systematic review and meta-analysis.