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Obesity, overweight not linked to hand osteoarthritis

04 Oct 2017

Hand osteoarthritis (OA) is not associated with overweight or obesity, reports a recent study. In addition, there are conflicting results for smoking and hand OA, which suggest lack of association.

Researchers included a total of 1,232 participants from the Osteoarthritis Initiative to examine the extent that overweight/obesity, smoking and alcohol were associated with prevalence and longitudinal changes of radiographic hand OA. Of these, 994 had 4-year follow-up data. Only those without hand OA at baseline (n=406) were included in the analyses on incident hand OA.

Exposure variables included overweight/obesity (body mass index [BMI], waist circumference), smoking (current/former, smoking pack-years) and alcohol consumption (drinks/week). Linear and logistic regression analyses were used to examine possible associations between baseline exposure variables and radiographic hand OA severity, erosive hand OA, incidence of hand OA and radiographic changes.

Researchers adjusted their analyses for age, sex and education.

Overweight or obesity was not associated with hand OA. Cross-sectional analyses revealed that current smoking was associated with less hand OA, while longitudinal analyses showed higher odds of incident hand OA in current smokers (odds ratio [OR], 2.20; 95 percent CI, 1.02 to 4.77).

Moderate alcohol consumption correlated with higher Kellgren-Lawrence sum score at baseline (1 to 3 drinks: OR, 1.55; 0.43 to 2.67) and increasing sum score during a 4-year follow-up (4 to 7 drinks: OR, 0.33; 0.01 to 0.64). Moderate alcohol consumption (1 to 7 drinks/week) significantly correlated with twofold higher odds of erosive hand OA. Additional adjustment for BMI gave similar strengths of associations.

“Moderate alcohol consumption was associated with hand OA severity, radiographic changes and erosive hand OA, warranting further investigation,” researchers said.

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Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
5 days ago
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