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Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
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Nimotuzumab-gemcitabine combo improves survival in metastatic pancreatic cancer patients

07 Aug 2017

The combination of nimotuzumab and gemcitabine is safe and well tolerated in the treatment of patients with locally advanced or metastatic pancreatic cancer, significantly improving 1-year overall survival (OS) and progression-free survival (PFS) rates especially in those with KRAS wild-type tumours, according to a study.

A total of 192 patients with previously untreated, unresectable, locally-advanced or metastatic pancreatic cancer were randomly assigned to receive gemcitabine (1,000 mg/m2, administered as a 30-minute infusion once weekly for 3 weeks, followed by a 1-week rest) plus either nimotuzumab (fixed dose of 400 mg as a 30-minute infusion) or placebo. Treatment was given until progression or unacceptable toxicity.

Of the patients, 186 (average age 63.6 years) were evaluated for efficacy and safety. The primary endpoint of OS was markedly higher in the nimotuzumab vs the placebo group (median, 8.6 vs 6.0 months; hazard ratio [HR], 0.69; p=0.0341). PFS was similarly better in the group receiving nimotuzumab (median, 5.1 vs 3.4 months; HR, 0.68; p=0.0163).

The corresponding 1-year OS and PFS were 34 and 22 percent for the gemcitabine plus nimotuzumab group vs 19 and 10 percent for the gemcitabine plus placebo group (HR for OS, 0.69; p=0.03; HR for PFS, 0.68; p=0.02).

Of note was the significantly better OS observed among patients with KRAS wild-type tumours than those with KRAS mutations (11.6 vs 5.6 months; p=0.03).

In terms of safety, very few grade 3/4 toxicities were reported. Commonly reported adverse events in the gemcitabine plus nimotuzumab group included chills, fatigue and pyrexia.

Nearly always fatal, pancreatic cancer has a 5-year survival rate of below 5 percent. Palliative chemotherapy remains the treatment of choice, given that most patients present with advanced disease. [Ann Oncol 2013;24:792-800; Ther Adv Med Oncol 2015;7:68-84; Oncology (Williston Park) 2014;28:70-74]

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Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
11 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 13 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.