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Myopic choroidal neovascularization eyes exhibit larger increases in axial length

18 Jul 2017
Recently, researchers made a breakthrough discovery by developing a revolutionary eye-drop as a new treatment for age-related blindness.

In a Japanese population, highly myopic eyes show greater increases in axial length than nonmyopic eyes, a new retrospective longitudinal study shows. In particular, eyes with myopic choroidal neovascularization (CNV) show the greatest increases.

Over a median follow-up of 28.7±16.8 months, non-highly myopic eyes (n=85) showed significant increase in axial length from baseline to final examination (23.58±1.0 vs 23.60±1.0; p=0.008). The same trend was observed in highly myopic eyes.

Particularly, baseline and final examination axial length of eyes without complications (n=165; 29.01±1.6 vs 29.11±1.6; p<0.0001), eyes with myopic traction maculopathy (MTM; n=32; 29.16±1.7 vs 29.24±1.7; p<0.0001) and CNV eyes (n=34; 29.47±1.3 vs 29.66±1.3; p<0.0001) were significantly different from each other.

The change in axial length per year (mm/year) was significantly greater in highly myopic eyes without complications (0.041±0.05) than in non-highly myopic eyes (0.007±.02; p<0.0001). Change per year in MTM eyes (0.040±0.05) was not significantly different from no complication eyes (p=0.91).

On the other hand, CNV eyes (0.081±0.04) had significantly greater changes in axial length per year compared with MTM eyes (p=0.0059) and highly myopic eyes without complications (p<0.0001).

Females (p=0.04) and those with CNV (p<0.0001) had significantly greater chances of greater changes in axial length per year, according to multiple regression analysis.

A total of 316 eyes of 316 patients (mean age 63.8±9.0 years) with best-corrected visual acuity of 0.6 decimal fraction were included in the study. Eyes with severe cataracts, poor fixation and histories of surgery were excluded.

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Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
5 days ago
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