Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Mycophenolic acid maintenance reduces flare rate in lupus nephritis

26 Sep 2017
Lupus, while difficult to diagnose, and a challenge to treat, need not be a death sentence.

Effective induction of immunosuppression and mycophenolic acid (MPA) as maintenance treatment has resulted in a relatively low flare rate for lupus nephritis in recent years, according to a study.

The investigators analysed data on 139 Chinese patients with class III/IV±V lupus nephritis diagnosed from January 1983 to December 2013. They also compared data before and after 1998 when maintenance immunosuppression was changed from azathioprine (AZA) to MPA.

A total of 135 episodes of renal flare occurred during 112.5±88.4 months, yielding a flare rate of 0.108 episodes per patient-year. Calculated from the start of induction treatment, the rate of renal relapse-free survival was 96 percent at 1 year, 90 percent at 2 years, 86 percent at 3 years, 80 percent at 4 years, 69 percent at 5 years and 57 percent at 10 years.

Lower flare risk correlated with MPA maintenance (odds ratio [OR], 0.314; 95 percent CI, 0.099 to 0.994; p=0.049), complete remission after induction immunosuppression (OR, 0.329; 0.133 to 0.810; p=0.016) and diagnosis after 1998 (OR, 0.305; 0.133 to 0.700; p=0.005).

Patients treated with prednisolone and MPA as maintenance immunosuppression had significantly better relapse-free survival (91 percent after 5 years and 83 percent after 10 years, respectively) compared with those who received prednisolone and AZA (70 and 52 percent, respectively; p=0.044).

Lupus nephritis diagnosed between 1998 and 2013 showed 5- and 10-year relapse-free survival rates of 93 and 86 percent, respectively, compared with 81 and 66 percent, respectively (p=0.017) for lupus nephritis that presented between 1983 and 1997.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.