Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
18 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 20 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Multidisciplinary management of HCC improves therapy access, patient survival

22 Sep 2017
Constant changes in the healthcare system have warranted the need for continuous updates and improvements in the structure of the orientation programme.

Management of patients with hepatocellular carcinoma (HCC) through a multidisciplinary tumour board (MDTB) results in significantly higher rates of receipt of therapy and improved survival, according to a recent study.

Researchers conducted a database analysis of all patients with HCC managed through MDTB from 2007 until 2011 to determine and compare utilization of therapies and outcomes for HCC patients managed through MDTB with those who were not. They also created a database of all HCC patients from 2002 to 2011, not managed through MDTB.

There were 306 patients with HCC managed through MDTB from 2007 to 2011 compared with 349 from 2002 to 2011 who were not.

No significant differences were recorded in baseline demographic or model for end-stage liver disease at presentation. Patients managed through MDTB were associated with presentation at an earlier tumour stage and with lower serum alpha fetoprotein (AFP; p=0.007).

Patients managed through MDTB were more likely to receive any treatment for HCC (odds ratio, 2.80; 95 percent CI, 1.71 to 4.59; p<0.0001), independent of model for end-stage liver disease score, serum AFP and tumour stage. Also, patients managed through MDTB had significantly greater survival compared to those who were not (19.1±2.5 vs 7.6±0.9 months; p<0.0001).

Management through MDTB, receipt of any HCC treatment, lower serum AFP, receipt of liver transplant and T2 tumour stage were the independent predictors for improved survival.

“Given the complexity of managing [HCC], it is widely accepted that a multidisciplinary team approach (tumour boards) offers the best approach to individualize therapy,” according to researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Oncology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
18 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 20 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.