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More comorbidities in acromegaly patients without biochemical control

28 Jul 2017

Acromegaly patients with poor biochemical control have more comorbidities than their counterparts with good biochemical control, a new study reveals.

Of 121 included acromegaly patients (mean age 55.4±16.7 years; 55 percent male), 120 had insulin-like growth factor-I (IGF-1) values reported. Over the mean study period of 8.8 years, biochemical control was achieved in 65.8 percent (n=79) and not achieved in 34.2 percent (n=41).

New cases of hypertension and diabetes were recorded in 7.6 (n=6) and 3.8 (n=3) percent of controlled patients, respectively, and in 7.3 (n=3) and 9.8 (n=4) percent of uncontrolled patients, respectively.

New left ventricular hypertrophy (LVH) was observed in 8.9 (n=7) and 4.9 (n=2) percent of controlled and uncontrolled patients, respectively. No new cases of heart failure were reported.

Considering comorbidities observed at any time during care, hypertension and diabetes were observed in 41.8 (n=33) and 25.3 (n=20) percent of the controlled group and in 58.5 (n=24) and 41.5 (n=17) percent of the uncontrolled group.

Moreover, LVH was present in 11.4 percent (n=9) of controlled patients and in and 9.8 percent (n=4) uncontrolled patients, while heart failure was observed in 3.8 (n=3) and 7.3 (n=3) percent, respectively.

At baseline, mean IGF-1 levels were 260 percent of the upper limit of normal (ULN) in patients who later achieved biochemical control; mean last IGF-1 in these patients was 67.7 percent ULN. In those who did not achieve control, mean baseline and last IGF-1 measurements were 242 and 177.8 percent ULN, respectively.

Biochemical control was defined as having a last IGF-1 measurement of less than or equal to the ULN for the specific patient’s age and gender. Primary and secondary outcomes of the study were new onset comorbidities and comorbidities at any time during the study period, respectively.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.