Most Read Articles
5 days ago
Eating red meat may lead to cardiovascular (CV) target organ damage over a 4-year period, according to a recent study involving hypertensive American Indians.
5 days ago
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.
Jairia Dela Cruz, 2 days ago
Capecitabine appears to provide additional survival benefit in triple-negative breast cancer patients treated with standard chemotherapy, significantly improving disease-free survival and overall survival but potentially increasing adverse events consistent with the drug’s known toxicity profile, according to a meta-analysis.

Micronutrient levels vary in patients with Down syndrome

4 days ago

Patients with Down syndrome (DS) have lower blood concentrations of zinc, selenium and calcium, and higher blood cell levels of copper and zinc, according to a systematic review.

Studies that measured micronutrient levels in whole blood, hair, saliva, red cell, serum and plasma samples of DS patients and controls were searched from the databases of PubMed, Web of Knowledge and Scopus. Those that measured protein and mRNA expression were excluded. A total of 69 studies met the inclusion criteria.

The Newcastle-Ottawa scale was used to assess methodological quality of the eligible observational studies. Information extracted from the studies included type of specimen, study sample characteristics, assay used and micronutrient levels.

Five comparisons (cases n=83; controls n=125) showed that red blood cell (RBC) levels of copper were significantly higher in patients with DS than in controls (standardized mean difference [SMD], 2.77; 95 percent CI, 1.96 to 3.57; p<0.00001).

Selenium concentration in the blood (SMD, -0.99; -1.55 to -0.43; p=0.0006), serum (SMD, -0.60; -0.97 to -0.23; p=0.001) and whole blood (SMD, -2.60; -3.32 to -1.89; p<0.00001) were significantly lower in DS cases.

Additionally, while blood calcium was significantly lower in DS cases (SMD, -0.63; -1.16 to -0.09; p=0.02), salivary levels were significantly higher (SMD, 0.85; 0.38 to 1.33; p=0.0004). Salivary sodium was significantly elevated in DS cases (SMD, 1.04; 0.39 to 1.69; p=0.002).

Blood (SMD, -1.30; -1.75 to -0.84; p<0.00001), plasma (SMD, -1.23; -1.93 to -0.54; p=0.0005), serum (SMD, -1.44; -1.93 to -0.95; p<0.00001) and hair (SMD, -0.54; -0.97 to -0.12; p=0.01) zinc concentrations were significantly lower in patients with DS, while RBC zinc (SMD, 2.62; 1.59 to 3.66; p<0.00001) was higher.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
5 days ago
Eating red meat may lead to cardiovascular (CV) target organ damage over a 4-year period, according to a recent study involving hypertensive American Indians.
5 days ago
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.
Jairia Dela Cruz, 2 days ago
Capecitabine appears to provide additional survival benefit in triple-negative breast cancer patients treated with standard chemotherapy, significantly improving disease-free survival and overall survival but potentially increasing adverse events consistent with the drug’s known toxicity profile, according to a meta-analysis.