Most Read Articles
01 May 2017
Body mass index (BMI), body fat and waist circumference are highly correlated, and all show an association with aggressive prostate cancer, according to a study.
21 Jun 2017
Podcast: Dr Steven Marso speaks about the cardiovascular safety of insulin degludec vs insulin glargine in patients with type 2 diabetes with high cardiovascular risk.
Roshini Claire Anthony, 20 Jun 2017

Adults with type 1 diabetes (T1D) who are prescribed metformin experience reductions in atherosclerosis progression and LDL cholesterol, according to results of the REMOVAL* study. However, the impact of metformin on glycaemic control in these patients is limited.

Christina Lau, 21 Jun 2017

Denosumab brings greater gains in spine and hip bone mineral density (BMD) than risedronate in glucocorticoid-treated patients at risk of osteoporotic fracture, according to results of a phase III study presented at the European League Against Rheumatism (EULAR) Annual Congress 2017 in Madrid, Spain.

Metabolic syndrome not associated with knee osteoarthritis

09 May 2017

Metabolic syndrome (MetS) or its components show no relationship with incident knee osteoarthritis (OA), although there may be an association with high blood pressure that requires further investigation, according to the results of the Framingham OA study.

The study included 991 individuals (mean age 54.2 years; 55.1 percent female). OA evaluations were conducted in 1992 to 1995 and in 2002 to 2005, while MetS component assessment was done right after the baseline visit.

Incident radiographic OA (ROA) was defined as having a Kellgren and Lawrence grade ≥2 at follow-up, whereas incident symptomatic OA (SxOA) was described as the development of the new combination of ROA and knee pain.

Binary regression analysis with generalized estimating equations was used to test the association of MetS (according to the Adult Treatment Panel III criteria) and its components with the risk of incident ROA and SxOA before and after adjustment for body mass index (BMI).  

Results showed that 26.7 percent of men and 22.9 percent of women had MetS. Initially, MetS and many of its components were associated with both incident ROA and SxOA. However, these associations were substantially attenuated and became nonsignificant after controlling for BMI and body weight.

Of note, an association between high blood pressure, particularly diastolic pressure, and SxOA persisted in both men and women.

MetS ups the risk of cardiovascular disease and mortality. Its components include central obesity, dyslipidaemia, impaired fasting glucose and hypertension. Several studies have reported an association between central obesity and BMI, which is a well-known risk factor for knee OA. Other mechanisms by which MetS components may influence the occurrence of OA are low-grade inflammation, alteration of the microvasculature of subchondral bone and neuromuscular impairment. [Cardiol Res Pract 2014;2014:21; Curr Opin Rheumatol 2010;22:533-7; Rheumatology (Oxford) 2007;46:1763-8; Ann Rheum Dis 2011;70:1354-6]

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Most Read Articles
01 May 2017
Body mass index (BMI), body fat and waist circumference are highly correlated, and all show an association with aggressive prostate cancer, according to a study.
21 Jun 2017
Podcast: Dr Steven Marso speaks about the cardiovascular safety of insulin degludec vs insulin glargine in patients with type 2 diabetes with high cardiovascular risk.
Roshini Claire Anthony, 20 Jun 2017

Adults with type 1 diabetes (T1D) who are prescribed metformin experience reductions in atherosclerosis progression and LDL cholesterol, according to results of the REMOVAL* study. However, the impact of metformin on glycaemic control in these patients is limited.

Christina Lau, 21 Jun 2017

Denosumab brings greater gains in spine and hip bone mineral density (BMD) than risedronate in glucocorticoid-treated patients at risk of osteoporotic fracture, according to results of a phase III study presented at the European League Against Rheumatism (EULAR) Annual Congress 2017 in Madrid, Spain.