Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 
Audrey Abella, 16 Oct 2017
The use of angiotensin converting enzyme (ACE) inhibitors may prevent repeat revascularization in patients who underwent percutaneous transluminal angioplasty (PTA) for peripheral artery disease (PAD) compared with angiotensin receptor blockers (ARB), according to a presentation at APCH 2017.

Mannitol reduces cisplatin-induced nephrotoxicity in patients with cancer

08 Sep 2017

Mannitol administration lowers the incidence and severity of nephrotoxicity in patients treated with cisplatin, a recent study suggests.

Researchers performed a quasi-experimental retrospective analysis, approved by the Institutional Review Board of inpatient and outpatient adults receiving cisplatin doses ≥40 mg/m2, to investigate the effect of mannitol on renal function and describe the incidence of cisplatin-induced nephrotoxicity.

There were 313 patients (95 treated with mannitol and 218 without) included in the analysis. The mean change in serum creatinine from baseline was the primary outcome, and incidences of various grades of nephrotoxicity were the secondary outcomes.

Patients who received mannitol had lower average increase in serum creatinine compared with those who did not (0.30 vs 0.47 mg/dL; 95 percent CI, 0.03 to 0.31 for difference; p=0.02). Mannitol-receiving patients also had fewer occurrences of ≥grade 2 nephrotoxicity compared with those who did not (8 vs 17 percent; p=0.04).

Furthermore, nongynaecologic regimens (6 vs 23 percent; p=0.001) and those who received doses ≥70 mg/m2 of cisplatin (7 vs 22 percent; p=0.03) had reduced rates of ≥grade 2 nephrotoxicity with mannitol.

“The results of the study suggest mannitol may be most effective when used with nongynaecologic regimens and with cisplatin doses ≥70 mg/m2,” researchers said.

“Cisplatin-induced nephrotoxicity is a dose limiting adverse effect that occurs in nearly one-third of patients. Mannitol administration has been used as a means to negate this toxicity,” they added.

In another study, researchers found that the addition of mannitol to saline hydration lowered the incidence of grade 3 increases in serum creatinine in patients with squamous cell cancer of the head and neck. Hyponatremia was also likely to occur in the mannitol group. [Support Care Cancer 2016;24:1789-93]

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Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 
Audrey Abella, 16 Oct 2017
The use of angiotensin converting enzyme (ACE) inhibitors may prevent repeat revascularization in patients who underwent percutaneous transluminal angioplasty (PTA) for peripheral artery disease (PAD) compared with angiotensin receptor blockers (ARB), according to a presentation at APCH 2017.