Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Lower serum vitamin E tied to higher colorectal cancer risk

29 Jul 2017

Lower serum vitamin E concentrations are associated with elevated risks of colorectal cancer (CRC), according to a new meta-analysis.

Pooled data from 11 studies over 10 publications (n=6,431; 520 cases; 5,981 controls) showed that mean serum vitamin E concentrations was significantly lower in CRC patients than in controls with a weighted mean difference (WMD) of -2.994 µmol/L (95 percent CI, -4.395 to -1.591 µmol/L; p<0.001).

Significant heterogeneity was detected in the results (p<0.001); subgroup analyses were performed to identify the source.

Subgroup analysis by ethnicity showed that lower serum vitamin E levels were associated with higher CRC risks (WMD, -1.82; -3.00 to -0.65 µmol/L; p=0.002). This trend was not significant in Asians (WMD, 11.01; -22.09 to 0.09 µmol/L; p=0.052).

Moreover, the association between vitamin E levels and CRC risk was significant only when cases were compared with hospital-based controls (WMD, -3.43; -6.27 to -0.59 µmol/L; p=0.018) but not with population-based controls.

The meta-analysis included case-control studies that assessed the relationship between CRC risk and levels of serum vitamin E. The databases of PubMed, Embase and China National Knowledge Infrastructure were accessed.

Among the information retrieved were cohort characteristics, vitamin E levels and disease incidence. The Newcastle-Ottawa scale (NOS) was used to assess methodological quality of the selected studies.

Of the 10 eligible publications, and out of a maximum of nine points in the NOS, three studies scored eight, six scored seven and two scored six.

Further prospective cohort studies are required to more accurately determine the effects of low vitamin E levels on CRC risk, according to researchers.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.