Low rate of DRMs, vertical transmission of HIV-1 among women treated with Option B+
A total of 124 HIV-1 positive pregnant women in Fort Portal, Uganda, were enrolled in the study. Blood samples were collected at their first visit to the antenatal clinic before initiating Option B+ as well as at 6 weeks and 6, 12, and 18 months postpartum. Viral load was determined by real-time RT-PCR and analyses were also made of vertical transmission. A total of 49 women (39.5 percent) were also included in a DRM analysis. Virological failure was defined as >1,000 copies HIV-1 RNA/mL.
At 1-year postpartum, three women were found to have virological failure, and seven were affected by the 18-month time point. No vertical transmission of HIV-1 was noted among the 49 mother-infant pairs included in the DRM analysis. However, three women had developed DRMs, and two had dual-class resistance against all recommended first-line drugs.
The researchers suggested that their findings of a low DRM selection rate support the continued adoption of the Option B+ for preventing mother-to-child transmission of HIV-1.